Engineering stem cell self-organization to build better organoids

JA Brassard, MP Lutolf - Cell stem cell, 2019 - cell.com
Organoids form through self-organization processes in which initially homogeneous
populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern …

Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery

M Wang, Y Xin, H Cao, W Li, Y Hua, TJ Webster… - Biomaterials …, 2021 - pubs.rsc.org
Studies of nanomedicine have achieved dramatic progress in recent decades. However, the
main challenges that traditional nanomedicine has to overcome include low accumulation at …

Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells

Y Huang, L Meng, Q Nie, Y Zhou, L Chen, S Yang… - Nature Chemistry, 2021 - nature.com
Membrane proteins on the cell surface perform a myriad of biological functions; however,
ligand discovery for membrane proteins is highly challenging, because a natural cellular …

Non-genetic engineering of cells for drug delivery and cell-based therapy

Q Wang, H Cheng, H Peng, H Zhou, PY Li… - Advanced drug delivery …, 2015 - Elsevier
Cell-based therapy is a promising modality to address many unmet medical needs. In
addition to genetic engineering, material-based, biochemical, and physical science-based …

Cell-surface sensors for real-time probing of cellular environments

W Zhao, S Schafer, J Choi, YJ Yamanaka… - Nature …, 2011 - nature.com
The ability to explore cell signalling and cell-to-cell communication is essential for
understanding cell biology and developing effective therapeutics. However, it is not yet …

Colorimetric and ultrasensitive bioassay based on a dual-amplification system using aptamer and DNAzyme

L Tang, Y Liu, MM Ali, DK Kang, W Zhao… - Analytical chemistry, 2012 - ACS Publications
Rapid detection of ultralow amount of biomarkers in a biologically complex mixture remains
a major challenge. Herein, we report a novel aptamer-based protein detection assay that …

Drug delivery to the inflamed intestinal mucosa–targeting technologies and human cell culture models for better therapies of IBD

O Hartwig, MAS Boushehri, KS Shalaby… - Advanced Drug Delivery …, 2021 - Elsevier
Current treatment strategies for inflammatory bowel disease (IBD) seek to alleviate the
undesirable symptoms of the disorder. Despite the higher specificity of newer generation …

Chemically programmed cell adhesion with membrane-anchored oligonucleotides

NS Selden, ME Todhunter, NY Jee, JS Liu… - Journal of the …, 2012 - ACS Publications
Cell adhesion organizes the structures of tissues and mediates their mechanical, chemical,
and electrical integration with their surroundings. Here, we describe a strategy for chemically …

Programming cell-cell interactions through non-genetic membrane engineering

CM Csizmar, JR Petersburg, CR Wagner - Cell Chemical Biology, 2018 - cell.com
The ability to direct targeted intercellular interactions has the potential to enable and expand
the use of cell-based therapies for regenerative medicine, tissue engineering, and …

Interactions of mesenchymal stem cells with endothelial cells

SM Nassiri, R Rahbarghazi - Stem cells and development, 2014 - liebertpub.com
Recent years have witnessed the emergence of a considerable amount of data pertaining to
the application of bone marrow mesenchymal stem cells (MSCs) in promoting angiogenesis …