The role of neural plasticity in depression: from hippocampus to prefrontal cortex
W Liu, T Ge, Y Leng, Z Pan, J Fan, W Yang… - Neural …, 2017 - Wiley Online Library
Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in
depression. The changes in neural plasticity induced by stress and other negative stimuli …
depression. The changes in neural plasticity induced by stress and other negative stimuli …
Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
MJF Levy, F Boulle, HW Steinbusch… - …, 2018 - Springer
Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …
burden in western societies. It is associated with atrophy and impaired functioning of cortico …
Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations
M Van de Wouw, M Boehme, JM Lyte… - The Journal of …, 2018 - Wiley Online Library
Key points Chronic (psychosocial) stress changes gut microbiota composition, as well as
inducing behavioural and physiological deficits. The microbial metabolites short‐chain fatty …
inducing behavioural and physiological deficits. The microbial metabolites short‐chain fatty …
[HTML][HTML] Stress, social behavior, and resilience: insights from rodents
The neurobiology of stress and the neurobiology of social behavior are deeply intertwined.
The social environment interacts with stress on almost every front: social interactions can be …
The social environment interacts with stress on almost every front: social interactions can be …
Glutamate and GABA homeostasis and neurometabolism in major depressive disorder
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
Gut microbiome-derived ammonia modulates stress vulnerability in the host
P Wang, PF Wu, HJ Wang, F Liao, F Wang… - Nature Metabolism, 2023 - nature.com
Ammonia has been long recognized as a metabolic waste product with well-known
neurotoxic effects. However, little is known about the beneficial function of endogenous …
neurotoxic effects. However, little is known about the beneficial function of endogenous …
Prefrontal excitatory/inhibitory balance in stress and emotional disorders: evidence for over-inhibition
CE Page, L Coutellier - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …
Clemastine enhances myelination in the prefrontal cortex and rescues behavioral changes in socially isolated mice
Altered myelin structure and oligodendrocyte function have been shown to correlate with
cognitive and motor dysfunction and deficits in social behavior. We and others have …
cognitive and motor dysfunction and deficits in social behavior. We and others have …
Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress
K Ma, A Xu, S Cui, MR Sun, YC Xue… - Translational psychiatry, 2016 - nature.com
Major depression is a prevalent emotion disorder. Chronic stressful life in genetically
susceptible individuals is presumably a major etiology that leads to neuron and synapse …
susceptible individuals is presumably a major etiology that leads to neuron and synapse …
Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice
EH Lee, JY Park, HJ Kwon, PL Han - Nature Communications, 2021 - nature.com
Chronic stress induces adaptive changes in the brain via the cumulative action of
glucocorticoids, which is associated with mood disorders. Here we show that repeated daily …
glucocorticoids, which is associated with mood disorders. Here we show that repeated daily …