The role of neural plasticity in depression: from hippocampus to prefrontal cortex

W Liu, T Ge, Y Leng, Z Pan, J Fan, W Yang… - Neural …, 2017 - Wiley Online Library
Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in
depression. The changes in neural plasticity induced by stress and other negative stimuli …

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

MJF Levy, F Boulle, HW Steinbusch… - …, 2018 - Springer
Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations

M Van de Wouw, M Boehme, JM Lyte… - The Journal of …, 2018 - Wiley Online Library
Key points Chronic (psychosocial) stress changes gut microbiota composition, as well as
inducing behavioural and physiological deficits. The microbial metabolites short‐chain fatty …

[HTML][HTML] Stress, social behavior, and resilience: insights from rodents

AK Beery, D Kaufer - Neurobiology of stress, 2015 - Elsevier
The neurobiology of stress and the neurobiology of social behavior are deeply intertwined.
The social environment interacts with stress on almost every front: social interactions can be …

Glutamate and GABA homeostasis and neurometabolism in major depressive disorder

A Sarawagi, ND Soni, AB Patel - Frontiers in psychiatry, 2021 - frontiersin.org
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

Gut microbiome-derived ammonia modulates stress vulnerability in the host

P Wang, PF Wu, HJ Wang, F Liao, F Wang… - Nature Metabolism, 2023 - nature.com
Ammonia has been long recognized as a metabolic waste product with well-known
neurotoxic effects. However, little is known about the beneficial function of endogenous …

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: evidence for over-inhibition

CE Page, L Coutellier - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

Clemastine enhances myelination in the prefrontal cortex and rescues behavioral changes in socially isolated mice

J Liu, JL Dupree, M Gacias, R Frawley… - Journal of …, 2016 - Soc Neuroscience
Altered myelin structure and oligodendrocyte function have been shown to correlate with
cognitive and motor dysfunction and deficits in social behavior. We and others have …

Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress

K Ma, A Xu, S Cui, MR Sun, YC Xue… - Translational psychiatry, 2016 - nature.com
Major depression is a prevalent emotion disorder. Chronic stressful life in genetically
susceptible individuals is presumably a major etiology that leads to neuron and synapse …

Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice

EH Lee, JY Park, HJ Kwon, PL Han - Nature Communications, 2021 - nature.com
Chronic stress induces adaptive changes in the brain via the cumulative action of
glucocorticoids, which is associated with mood disorders. Here we show that repeated daily …