This review describes off-resonance R 1ρ relaxation dispersion NMR methods for
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …

Ribonucleic acid oligonucleotides (RNAs) play pivotal roles in cellular function
(riboswitches), chemical biology applications (SELEX‐derived aptamers), cell biology and …

Abstract N 6-Methyladenosine (m6A) is an abundant post-transcriptional RNA modification
that influences multiple aspects of gene expression. In addition to recruiting proteins, m6A …

The synthesis of thiolactone monomers that mimic natural nucleosides and engage in robust
ring opening polymerizations (ROP) is herein described. As each repeat unit contains a …

Fluorine labeling of ribonucleic acids (RNA) in conjunction with 19F NMR spectroscopy has
emerged as a powerful strategy for spectroscopic analysis of RNA structure and dynamics …

Understanding small molecule binding to RNA can be complicated by an intricate interplay
between binding stoichiometry, multiple binding motifs, different occupancies of different …

Site‐specific introduction of bioorthogonal handles into RNAs is in high demand for
decorating RNAs with fluorophores, affinity labels or other modifications. Aldehydes …

Many biochemical processes use the Watson–Crick geometry to distinguish correct from
incorrect base pairing. However, on rare occasions, mismatches such as G· T/U can …

New RNA modifications are needed to advance our toolbox for targeted manipulation of
RNA. In particular, the development of high-performance reporter groups facilitating …

The investigation of non‐coding RNAs requires RNAs containing modifications at every
possible position within the oligonucleotide. Here, we present the chemo‐enzymatic RNA …