Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

1. Introduction Administration Heart Failure Trial) and other trials suggest that death is
disproportionately sudden in patients with Over 2 million Americans suffer from heart failure …

The quantitative analysis of the contribution of ion fluxes through membrane channels to
changes of intracellular ion concentrations would benefit from the exact knowledge of the …

Mathematical models were developed to reconstruct the action potentials (AP) recorded in
epicardial and endocardial myocytes isolated from the adult rat left ventricle. The main goal …

Recently, we found that repolarization heterogeneities between subepicardial and
midmyocardial cells can form a substrate for reentrant ventricular arrhythmias in failing …

Prolongation of action potential duration is the most consistent electrophysiological
abnormality in myocardium and myocytes from hypertrophied and failing hearts …

A number of gender differences exist in the human electrocardiogram (ECG): the P-wave
and PR intervals are slightly longer in men than in women, whilst women have higher …

After myocardial infarction (MI), the noninfarcted myocardium undergoes significant
hypertrophy as part of the post-MI structural remodeling. Electrophysiological changes …