With rapid advances in sequencing technologies, tremendous progress has been made in
understanding the molecular pathogenesis of acute myeloid leukaemia (AML), thus …

Chromatin-binding proteins are critical regulators of cell state in haematopoiesis,. Acute
leukaemias driven by rearrangement of the mixed lineage leukaemia 1 gene (KMT2A r) or …

The BCL6 corepressor (BCOR) is a transcription factor involved in the control of
embryogenesis, mesenchymal stem cells function, hematopoiesis, and lymphoid …

Dysregulation of the oncogenic transcription factor HOXA9 is a prominent feature for most
aggressive acute myeloid leukemia cases and a strong indicator of poor prognosis in …

Menin/MEN1 is a scaffold protein that participates in proliferation, regulation of gene
transcription, DNA damage repair, and signal transduction. In hematological malignancies …

Differentiation Syndrome (DS) has been identified in a subset of patients undergoing
treatment with novel classes of differentiating therapies for acute myeloid leukemia (AML) …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The standard
of care in medically and physically fit patients is intensive induction therapy. The majority of …

Epigenetic deregulation is now a well-recognized although not yet fully understood
mechanism that contributes to the development and progression of myeloid malignancies. In …

Simple Summary Despite recent, rapid drug development success for patients with acute
myeloid leukemia, distinct molecular and genetic aberrations still confer a poor prognosis. In …

Abstract Purpose of Review Acute myeloid leukemia (AML) is an aggressive malignancy of
the bone marrow that has a poor prognosis with traditional cytotoxic chemotherapy …