[HTML][HTML] Methods used to evaluate pain behaviors in rodents
Rodents are commonly used to study the pathophysiological mechanisms of pain as studies
in humans may be difficult to perform and ethically limited. As pain cannot be directly …
in humans may be difficult to perform and ethically limited. As pain cannot be directly …
Pharmacological inhibition of the nod-like receptor family pyrin domain containing 3 inflammasome with MCC950
SE Corcoran, R Halai, MA Cooper - Pharmacological reviews, 2021 - ASPET
Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1 β and IL-18 and induces …
drives release of the proinflammatory cytokines interleukin (IL)-1 β and IL-18 and induces …
[HTML][HTML] MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice
MCC950 a potent, highly specific small molecule inhibitor of canonical and noncanonical
activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven …
activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven …
Activation of NLRP3 inflammasome in peripheral nerve contributes to paclitaxel-induced neuropathic pain
M Jia, C Wu, F Gao, H Xiang, N Sun, P Peng… - Molecular …, 2017 - journals.sagepub.com
Background Paclitaxel is commonly used as a cancer chemotherapy drug that frequently
causes peripheral neuropathic pain. Inflammasome is a multiprotein complex consisting of …
causes peripheral neuropathic pain. Inflammasome is a multiprotein complex consisting of …
Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment
Objective This review aims to examine the available literature on the epidemiology,
pathophysiology, and treatment of burn-induced pain. Methods A search was conducted on …
pathophysiology, and treatment of burn-induced pain. Methods A search was conducted on …
[HTML][HTML] The NLRP3 inflammasome: role and therapeutic potential in pain treatment
H Starobova, EI Nadar, I Vetter - Frontiers in Physiology, 2020 - frontiersin.org
Pain is a fundamental feature of inflammation. The immune system plays a critical role in the
activation of sensory neurons and there is increasing evidence of neuro-inflammatory …
activation of sensory neurons and there is increasing evidence of neuro-inflammatory …
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release
H Starobova, M Monteleone, C Adolphe… - Journal of Experimental …, 2021 - rupress.org
Disclosures: K. Schroder reported" other" from Inflazome Ltd outside the submitted work; in
addition, K. Schroder had a patent to PCT/EP2017/053498 licensed (Inflazome Ltd), a patent …
addition, K. Schroder had a patent to PCT/EP2017/053498 licensed (Inflazome Ltd), a patent …
Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain
The therapeutic effect of electroacupuncture (EA) on inflammatory pain has been well
recognized clinically. The inflammasome promotes the maturation of the inflammatory …
recognized clinically. The inflammasome promotes the maturation of the inflammatory …
Upregulation of NLRP3 via STAT3-dependent histone acetylation contributes to painful neuropathy induced by bortezomib
CC Liu, ZX Huang, X Li, KF Shen, M Liu… - Experimental …, 2018 - Elsevier
Painful neuropathy, as a severe side effect of chemotherapeutic bortezomib, is the most
common reason for treatment discontinuation. However, the mechanism by which …
common reason for treatment discontinuation. However, the mechanism by which …
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain
The NOD-like receptor (NLR) family pyrin domain-containing protein 3 (NLRP3)
inflammasome is implicated in the pathogenesis of multiple diseases including …
inflammasome is implicated in the pathogenesis of multiple diseases including …