Pulmonary hypertension (PH) describes heterogeneous population of patients with a mean
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …

Pulmonary hypertension (PH) is a progressive disease that arises from multiple etiologies
and ultimately leads to right heart failure as the predominant cause of morbidity and …

Pulmonary arterial hypertension (PAH) is a severe disease with high morbidity and mortality.
Current therapies are mainly focused on vasodilative agents to improve prognosis …

A central feature of progressive vascular remodeling is altered smooth muscle cell (SMC)
homeostasis; however, the understanding of how different cell populations contribute to this …

Pulmonary mesenchymal cells are critical players in both the mouse and human during lung
development and disease states. They are increasingly recognized as highly …

Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung
diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive …

Background: Pulmonary arterial hypertension (PAH) is a fatal disease characterized by
profound vascular remodeling in which pulmonary arteries narrow because of medial …

Objective: Excessive accumulation of resident cells within the pulmonary vascular wall
represents the hallmark feature of the remodeling occurring in pulmonary arterial …

Pericytes are mesenchymal-derived mural cells localized within the basement membrane of
pulmonary and systemic capillaries. Besides structural support, pericytes control vascular …

Background: Perivascular fibrosis, characterized by increased amount of connective tissue
around vessels, is a hallmark for vascular disease. Ang II (angiotensin II) contributes to …