Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
Advances and current challenges in calcium signaling
Content Summary 414 I. Introduction 415 II. Ca2+ importer and exporter in plants 415 III. The
Ca2+ decoding toolkit in plants 415 IV. Mechanisms of Ca2+ signal decoding 417 V …
Ca2+ decoding toolkit in plants 415 IV. Mechanisms of Ca2+ signal decoding 417 V …
[HTML][HTML] The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
K Cosentino, V Hertlein, A Jenner, T Dellmann… - Molecular cell, 2022 - cell.com
BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial
outer membrane permeabilization. However, the mechanism by which they assemble the …
outer membrane permeabilization. However, the mechanism by which they assemble the …
DRP1 interacts directly with BAX to induce its activation and apoptosis
A Jenner, A Peña‐Blanco, R Salvador‐Gallego… - The EMBO …, 2022 - embopress.org
The apoptotic executioner protein BAX and the dynamin‐like protein DRP1 co‐localize at
mitochondria during apoptosis to mediate mitochondrial permeabilization and …
mitochondria during apoptosis to mediate mitochondrial permeabilization and …
Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology
RG Abrisch, SC Gumbin, BT Wisniewski… - Journal of Cell …, 2020 - rupress.org
The steady-state morphology of the mitochondrial network is maintained by a balance of
constitutive fission and fusion reactions. Disruption of this steady-state morphology results in …
constitutive fission and fusion reactions. Disruption of this steady-state morphology results in …
Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles
INTRODUCTION The cytoplasm contains an unconventional class of organelles that
concentrate specific factors and resources without a limiting membrane. These …
concentrate specific factors and resources without a limiting membrane. These …
An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D− TSG101 interactions
J Wang, N Fang, J Xiong, Y Du, Y Cao, WK Ji - Nature communications, 2021 - nature.com
Upon starvation, cells rewire their metabolism, switching from glucose-based metabolism to
mitochondrial oxidation of fatty acids, which require the transfer of FAs from lipid droplets …
mitochondrial oxidation of fatty acids, which require the transfer of FAs from lipid droplets …
An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion
TT Nguyen, GK Voeltz - Elife, 2022 - elifesciences.org
Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified
platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites …
platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites …
Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities
Unravelling the dynamic molecular interplay behind complex physiological processes such
as neuronal plasticity requires the ability to both detect minute changes in biochemical …
as neuronal plasticity requires the ability to both detect minute changes in biochemical …
Applications and advances of metabolite biosensors for metabolic engineering
Quantification and regulation of pathway metabolites is crucial for optimization of microbial
production bioprocesses. Genetically encoded biosensors provide the means to couple …
production bioprocesses. Genetically encoded biosensors provide the means to couple …