Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks

EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Advances and current challenges in calcium signaling

J Kudla, D Becker, E Grill, R Hedrich, M Hippler… - New …, 2018 - Wiley Online Library
Content Summary 414 I. Introduction 415 II. Ca2+ importer and exporter in plants 415 III. The
Ca2+ decoding toolkit in plants 415 IV. Mechanisms of Ca2+ signal decoding 417 V …

[HTML][HTML] The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

K Cosentino, V Hertlein, A Jenner, T Dellmann… - Molecular cell, 2022 - cell.com
BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial
outer membrane permeabilization. However, the mechanism by which they assemble the …

DRP1 interacts directly with BAX to induce its activation and apoptosis

A Jenner, A Peña‐Blanco, R Salvador‐Gallego… - The EMBO …, 2022 - embopress.org
The apoptotic executioner protein BAX and the dynamin‐like protein DRP1 co‐localize at
mitochondria during apoptosis to mediate mitochondrial permeabilization and …

Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology

RG Abrisch, SC Gumbin, BT Wisniewski… - Journal of Cell …, 2020 - rupress.org
The steady-state morphology of the mitochondrial network is maintained by a balance of
constitutive fission and fusion reactions. Disruption of this steady-state morphology results in …

Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles

JE Lee, PI Cathey, H Wu, R Parker, GK Voeltz - Science, 2020 - science.org
INTRODUCTION The cytoplasm contains an unconventional class of organelles that
concentrate specific factors and resources without a limiting membrane. These …

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D− TSG101 interactions

J Wang, N Fang, J Xiong, Y Du, Y Cao, WK Ji - Nature communications, 2021 - nature.com
Upon starvation, cells rewire their metabolism, switching from glucose-based metabolism to
mitochondrial oxidation of fatty acids, which require the transfer of FAs from lipid droplets …

An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion

TT Nguyen, GK Voeltz - Elife, 2022 - elifesciences.org
Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified
platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites …

Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities

S Mehta, Y Zhang, RH Roth, J Zhang, A Mo… - Nature cell …, 2018 - nature.com
Unravelling the dynamic molecular interplay behind complex physiological processes such
as neuronal plasticity requires the ability to both detect minute changes in biochemical …

Applications and advances of metabolite biosensors for metabolic engineering

D Liu, T Evans, F Zhang - Metabolic engineering, 2015 - Elsevier
Quantification and regulation of pathway metabolites is crucial for optimization of microbial
production bioprocesses. Genetically encoded biosensors provide the means to couple …