The effect of the bacterial heat-stable nucleoid-structuring (H-NS) protein on gene
expression is overwhelmingly negative and extends throughout the genome, pointing to an …

The bacterial chromosomal DNA is folded into a compact structure called nucleoid. The
shape and size of this 'body'is determined by a number of factors. Major players are DNA …

Short runs of adenines are a ubiquitous DNA element in regulatory regions of many
organisms. When runs of 4–6 adenine base pairs ('A-tracts') are repeated with the helical …

Histone-like proteins in bacteria contribute to the control of gene expression, as well as
participating in other DNA transactions such as recombination and DNA replication. They …

Polyamines are small polycationic molecules found in almost all cells and associated with a
wide variety of physiological processes. In recent years it has become increasingly clear …

The transcriptional antisilencer VirB acts as a master regulator of virulence gene expression
in the human pathogen Shigella flexneri. It binds DNA sequences (virS) upstream of VirB …

Fis is a key DNA-binding protein involved in nucleoid organization and modulation of many
DNA transactions, including transcription in enteric bacteria. The regulon of genes whose …

Nitric oxide produced by activated macrophages plays a key role as one of the immune
system's weapons against pathogens. Because the lifetime of nitric oxide is short in aerobic …

In the human enteropathogen Shigella transcription of virF, the primary regulator of the
invasion functions, is strictly temperature‐dependent and is antagonistically mediated by H …

Legionella are opportunistic pathogens that develop in aquatic environments where they
multiply in protozoa. When infected aerosols reach the human respiratory tract they may …