CD4 T-cell subsets and the pathophysiology of inflammatory bowel disease

R Gomez-Bris, A Saez, B Herrero-Fernandez… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …

Cytokine-mediated crosstalk between immune cells and epithelial cells in the gut

M Mahapatro, L Erkert, C Becker - Cells, 2021 - mdpi.com
Cytokines are small proteins that are secreted by a vast majority of cell types in the gut. They
not only establish cell-to-cell interactions and facilitate cellular signaling, but also regulate …

A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease

Q Zhang, H Tao, Y Lin, Y Hu, H An, D Zhang, S Feng… - Biomaterials, 2016 - Elsevier
Oxidative stress, resulting from excessive generation of reactive oxygen species (ROS),
plays a pivotal role in the initiation and progression of inflammatory bowel disease (IBD). To …

Recent advances: the imbalance of cytokines in the pathogenesis of inflammatory bowel disease

Q Guan, J Zhang - Mediators of inflammation, 2017 - Wiley Online Library
Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease
(IBD), including Crohn's disease and ulcerative colitis, where they drive and regulate …

IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair

LR Lopetuso, C De Salvo, L Pastorelli… - Proceedings of the …, 2018 - National Acad Sciences
Defective and/or delayed wound healing has been implicated in the pathogenesis of several
chronic inflammatory disorders, including inflammatory bowel disease (IBD). The resolution …

Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical …

YK Marquez-Flores, I Villegas, A Cardeno… - The Journal of nutritional …, 2016 - Elsevier
The present study was designed to elucidate the protective effects of dietary apigenin (API)
enrichment in a chronic colitis model induced by DSS in mice. Inflammatory mediators and …

IL-33's role in the gut immune system: a comprehensive review of its crosstalk and regulation

H Kaur, G Kaur, SA Ali - Life Sciences, 2023 - Elsevier
The intestinal tract is the largest immune organ in the human body, comprising a complex
network of immune cells and epithelial cells that perform a variety of functions such as …

Baicalin may alleviate inflammatory infiltration in dextran sodium sulfate-induced chronic ulcerative colitis via inhibiting IL-33 expression

CL Zhang, S Zhang, WX He, JL Lu, YJ Xu, JY Yang… - Life sciences, 2017 - Elsevier
Aims To investigate the therapeutic effect of baicalin treatment in chronic ulcerative colitis
(UC), and explore the potential anti-inflammation mechanism (s) via IL-33 pathway. Main …

Chronic colitis induces meninges traffic of gut-derived T cells, unbalances M1 and M2 microglia/macrophage and increases ischemic brain injury in mice

Y Feng, X He, S Luo, X Chen, S Long, F Liang, T Shi… - Brain research, 2019 - Elsevier
Ischemic stroke is one of the most common diseases leading to death and is the primary
cause of physical handicap. Recent studies have reported that chronic colitis increases the …

The role of the IL-33/ST2 axis in autoimmune disorders: friend or foe?

X Liu, Y Xiao, Y Pan, H Li, SG Zheng, W Su - Cytokine & growth factor …, 2019 - Elsevier
Autoimmune diseases (ADs), which are common immune-mediated inflammatory
syndromes, are characterized by an imbalance between T effector (Th) 1/Th17 cells and T …