New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

The amazing potential of fungi: 50 ways we can exploit fungi industrially

KD Hyde, J Xu, S Rapior, R Jeewon, S Lumyong… - Fungal Diversity, 2019 - Springer
Fungi are an understudied, biotechnologically valuable group of organisms. Due to the
immense range of habitats that fungi inhabit, and the consequent need to compete against a …

antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation

K Blin, S Shaw, HE Augustijn, ZL Reitz… - Nucleic acids …, 2023 - academic.oup.com
Microorganisms produce small bioactive compounds as part of their secondary or
specialised metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal …

antiSMASH 6.0: improving cluster detection and comparison capabilities

K Blin, S Shaw, AM Kloosterman… - Nucleic acids …, 2021 - academic.oup.com
Many microorganisms produce natural products that form the basis of antimicrobials,
antivirals, and other drugs. Genome mining is routinely used to complement screening …

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

K Blin, S Shaw, K Steinke, R Villebro… - Nucleic acids …, 2019 - academic.oup.com
Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …

A new genomic blueprint of the human gut microbiota

A Almeida, AL Mitchell, M Boland, SC Forster, GB Gloor… - Nature, 2019 - nature.com
The composition of the human gut microbiota is linked to health and disease, but knowledge
of individual microbial species is needed to decipher their biological roles. Despite …

Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

MGnify: the microbiome sequence data analysis resource in 2023

L Richardson, B Allen, G Baldi… - Nucleic Acids …, 2023 - academic.oup.com
Abstract The MGnify platform (https://www. ebi. ac. uk/metagenomics) facilitates the
assembly, analysis and archiving of microbiome-derived nucleic acid sequences. The …

A new antibiotic selectively kills Gram-negative pathogens

Y Imai, KJ Meyer, A Iinishi, Q Favre-Godal, R Green… - Nature, 2019 - nature.com
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative
pathogens,. These microorganisms have a highly restrictive permeability barrier, which limits …

Review on natural products databases: where to find data in 2020

M Sorokina, C Steinbeck - Journal of cheminformatics, 2020 - Springer
Natural products (NPs) have been the centre of attention of the scientific community in the
last decencies and the interest around them continues to grow incessantly. As a …