[HTML][HTML] Challenges and recent progress in oral drug delivery systems for biopharmaceuticals
B Homayun, X Lin, HJ Choi - Pharmaceutics, 2019 - mdpi.com
Routes of drug administration and the corresponding physicochemical characteristics of a
given route play significant roles in therapeutic efficacy and short term/long term biological …
given route play significant roles in therapeutic efficacy and short term/long term biological …
Foundations of gastrointestinal-based drug delivery and future developments
JN Chu, G Traverso - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …
administration owing to its convenience for patients, which improves adherence. However …
[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …
Non-invasive delivery strategies for biologics
AC Anselmo, Y Gokarn, S Mitragotri - Nature Reviews Drug Discovery, 2019 - nature.com
Biologics now constitute a significant element of available medical treatments. Owing to their
clinical and commercial success, biologics are a rapidly growing class and have become a …
clinical and commercial success, biologics are a rapidly growing class and have become a …
Oral drug delivery platforms for biomedical applications
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …
The current state of peptide drug discovery: back to the future?
A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
Antimicrobial peptides–Advances in development of therapeutic applications
The severe infection is becoming a significant health problem which threaten the lives of
patients and the safety and economy of society. In the way of finding new strategy …
patients and the safety and economy of society. In the way of finding new strategy …
An ingestible self-orienting system for oral delivery of macromolecules
Biomacromolecules have transformed our capacity to effectively treat diseases; however,
their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit …
their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit …
Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors
A Abramson, MR Frederiksen, A Vegge, B Jensen… - Nature …, 2022 - nature.com
Oral administration provides a simple and non-invasive approach for drug delivery.
However, due to poor absorption and swift enzymatic degradation in the gastrointestinal …
However, due to poor absorption and swift enzymatic degradation in the gastrointestinal …
Design principles of microneedles for drug delivery and sampling applications
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …
bioactive molecules for local or systemic therapies attributing to their minimally invasive …