Periodontal ligament stem cells: current knowledge and future perspectives

O Trubiani, J Pizzicannella, S Caputi… - Stem cells and …, 2019 - liebertpub.com
Teeth represent a fascinating area of study in regenerative medicine, because of their
unique and complex developmental origin. Several types of mesenchymal stem cells …

Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

FRS Passos, HG Araújo-Filho, BS Monteiro… - Phytomedicine, 2022 - Elsevier
Background Saponins are glycosides which, after acid hydrolysis, liberate sugar (s) and an
aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal saponins …

Three-dimensional printed PLA scaffold and human gingival stem cell-derived extracellular vesicles: a new tool for bone defect repair

F Diomede, A Gugliandolo, P Cardelli… - Stem Cell Research & …, 2018 - Springer
Background The role of bone tissue engineering in the field of regenerative medicine has
been a main research topic over the past few years. There has been much interest in the use …

Astragalus polysaccharides alleviates LPS‐induced inflammation via the NF‐κB/MAPK signaling pathway

N Dong, X Li, C Xue, L Zhang, C Wang… - Journal of cellular …, 2020 - Wiley Online Library
Early weaning usually causes intestinal disorders, enteritis, and diarrhea in young animals
and human infants. Astragalus polysaccharides (APS) possesses anti‐inflammatory activity …

Engineered extracellular vesicles from human periodontal-ligament stem cells increase VEGF/VEGFR2 expression during bone regeneration

J Pizzicannella, A Gugliandolo, T Orsini… - Frontiers in …, 2019 - frontiersin.org
Bone regeneration represents still a challenge, in particular for calvarium defects. Recently,
the development of biomaterials with the addiction of stem cells is giving promising results …

Curcumin/liposome nanotechnology as delivery platform for anti-inflammatory activities via NFkB/ERK/pERK pathway in human dental pulp treated with 2 …

B Sinjari, J Pizzicannella, M D'Aurora… - Frontiers in …, 2019 - frontiersin.org
Curcumin, primary component of the spice turmeric extracted from the rhizomes of Curcuma
longa, represents the major anti-oxidant and anti-inflammatory substance found in turmeric …

The Th17/Treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis

J Deng, C Lu, Q Zhao, K Chen, S Ma… - Journal of periodontal …, 2022 - Wiley Online Library
Periodontopathic bacteria constantly stimulate the host, which causes an immune response,
leading to host‐induced periodontal tissue damage. The complex interaction and imbalance …

Insight into the roles of melatonin in bone tissue and bone‑related diseases

X Lu, S Yu, G Chen, W Zheng… - International …, 2021 - spandidos-publications.com
Bone‑related diseases comprise a large group of common diseases, including fractures,
osteoporosis and osteoarthritis (OA), which affect a large number of individuals, particularly …

MicroRNA-21 down-regulates inflammation and inhibits periodontitis

W Zhou, L Su, X Duan, X Chen, A Hays… - Molecular …, 2018 - Elsevier
Periodontitis is one of the most prevalent inflammatory diseases, characterized by gingival
inflammation and alveolar bone loss. MicroRNAs (MiRNAs) are important regulators of …

In Vitro Anticancer Activity of Methanolic Extract of Justicia adhatoda Leaves with Special Emphasis on Human Breast Cancer Cell Line

S Kumar, R Singh, D Dutta, S Chandel, A Bhattacharya… - Molecules, 2022 - mdpi.com
Natural products are being targeted as alternative anticancer agents due to their non-toxic
and safe nature. The present study was conducted to explore the in vitro anticancer potential …