Chemotherapy combined with or without targeted therapy is the fundamental treatment for
metastatic colorectal cancer (mCRC). Due to the adverse effects of chemotherapeutic drugs …

Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

A key player in driving cellular immunity, IFN-γ is capable of orchestrating numerous
protective functions to heighten immune responses in infections and cancers. It can exhibit …

IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host
immunity. Several studies have found that IFNγ is involved in regulating tumor cell …

Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase
(JAK)/STAT signalling cascade and is best known for its essential role in mediating …

Objectives To characterise the sketetal muscle metabolic phenotype during early critical
illness. Methods Vastus lateralis muscle biopsies and serum samples (days 1 and 7) were …

Autophagy is a highly conserved catabolic process seen in eukaryotes and is essentially a
lysosome-dependent protein degradation pathway. The dysregulation of autophagy is often …

Autophagy is an intracellular degradation process responsible for the delivery of cellular
material to the lysosomes. One of the key mechanisms for control of autophagy is the …

Tumor-associated inflammation is predictive of poor prognosis and drives a variety of
tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis …

Autophagy is an evolutionarily conserved lysosome-dependent catabolic process which
degrades cell's components in order to recycle substrates to exert optimally and adapt to …