Calcium-sensing receptor (CaSR) is a plasma-membrane G protein-coupled receptor
activated by extracellular calcium and expressed in kidney tubular cells. It inhibits calcium …

Calcium (Ca2+) is a universal and vital intracellular messenger involved in a diverse range
of cellular and biological processes. Changes in the concentration of extracellular Ca2+ can …

G-protein-coupled receptors (GPCRs) are a target for over 34% of current drugs. The
calcium-sensing receptor (CaSR), a family C GPCR, regulates systemic calcium (Ca2+) …

Cadmium (Cd2+) exposure induces chronic kidney disease and renal cancers, which
originate from injury and cancerization of renal tubular cells. Previous studies have shown …

Clinical and fundamental research suggest that altered calcium and cAMP signaling might
be the most proximal events in ADPKD pathogenesis. Cells from ADPKD cysts have a …

High concentrations of urinary calcium counteract vasopressin action via the activation of the
calcium-sensing receptor (CaSR) that is expressed in the luminal membrane of collecting …

Vasopressin (AVP) increases water permeability in the renal collecting duct through the
regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and …

High concentrations of urinary calcium counteract vasopressin action via the activation of the
Calcium‐Sensing Receptor (CaSR) expressed in the luminal membrane of the collecting …

Aquaporin-2 (AQP2) is the vasopressin-regulated water channel that controls renal water
reabsorption and urine concentration. AQP2 undergoes different regulated post-translational …

Rainforest hunter–gatherers from Southeast Asia are characterized by specific
morphological features including a particularly dark skin color (D), short stature (S), woolly …