Therapeutic nanoparticles and their targeted delivery applications

AA Yetisgin, S Cetinel, M Zuvin, A Kosar, O Kutlu - Molecules, 2020 - mdpi.com
Nanotechnology offers many advantages in various fields of science. In this regard,
nanoparticles are the essential building blocks of nanotechnology. Recent advances in …

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

AP Singh, A Biswas, A Shukla, P Maiti - Signal transduction and …, 2019 - nature.com
The application of nanomedicines is increasing rapidly with the promise of targeted and
efficient drug delivery. Nanomedicines address the shortcomings of conventional therapy, as …

PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: Effects of formulation parameters

KY Hernández-Giottonini, RJ Rodríguez-Córdova… - Rsc Advances, 2020 - pubs.rsc.org
This study presents the influence of the primary formulation parameters on the formation of
poly-DL-lactic-co-glycolic nanoparticles by the emulsification-solvent evaporation, and the …

Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease

B Fonseca-Santos, MPD Gremião… - International Journal of …, 2015 - Taylor & Francis
Alzheimer's disease is a neurological disorder that results in cognitive and behavioral
impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs …

Controlled release and targeted drug delivery with poly (lactic-co-glycolic acid) nanoparticles: reviewing two decades of research

A Zeb, M Gul, TTL Nguyen, HJ Maeng - Journal of Pharmaceutical …, 2022 - Springer
Background Controlled release and targeted delivery of the drug payload are the two most
fascinating applications of nanoparticle-based systems explored in the recent past. The …

Overcoming the blood–brain barrier. challenges and tricks for CNS drug delivery

LA Bors, F Erdő - Scientia Pharmaceutica, 2019 - mdpi.com
Treatment of certain central nervous system disorders, including different types of cerebral
malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs …

Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting

M Fazil, S Md, S Haque, M Kumar, S Baboota… - European Journal of …, 2012 - Elsevier
The rivastigmine (RHT) loaded chitosan nanoparticles (CS-RHT NPs) were prepared by
ionic gelation method to improve the bioavailability and enhance the uptake of RHT to the …

Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: in vitro and in vivo studies

U Seju, A Kumar, KK Sawant - Acta biomaterialia, 2011 - Elsevier
Olanzapine (OZ) is a second-generation or atypical antipsychotic which selectively binds to
central dopamine D2 and serotonin (5-HT2c) receptors. It has poor bioavailability due to …

Nanotechnology-based drug delivery systems for Alzheimer's disease management: Technical, industrial, and clinical challenges

MM Wen, NS El-Salamouni, WM El-Refaie… - Journal of controlled …, 2017 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease with high prevalence in the
rapidly growing elderly population in the developing world. The currently FDA approved …

Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues

D Brambilla, B Le Droumaguet, J Nicolas… - … , Biology and Medicine, 2011 - Elsevier
Alzheimer's disease (AD) represents the most common form of dementia worldwide,
affecting more than 35 million people. Advances in nanotechnology are beginning to exert a …