Cells are crowded, but proteins are almost always studied in dilute aqueous buffer. We
review the experimental evidence that crowding affects the equilibrium thermodynamics of …

Molecular glue degraders are small, drug-like compounds that induce interactions between
an E3 ubiquitin ligase and a target, which result in ubiquitination and subsequent …

While the vast majority of well-structured single protein chains can now be predicted to high
accuracy due to the recent AlphaFold model, the prediction of multi-chain protein complexes …

INTRODUCTION Protein-protein interactions play critical roles in biology, but the structures
of many eukaryotic protein complexes are unknown, and there are likely many interactions …

DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of
Structure Prediction (CASP14) conference. We explored network architectures that …

Predicting the structure of interacting protein chains is a fundamental step towards
understanding protein function. Unfortunately, no computational method can produce …

We introduce Performers, Transformer architectures which can estimate regular (softmax)
full-rank-attention Transformers with provable accuracy, but using only linear (as opposed to …

Cellular functions are governed by molecular machines that assemble through protein-
protein interactions. Their atomic details are critical to studying their molecular mechanisms …

Predicting interactions between proteins and other biomolecules solely based on structure
remains a challenge in biology. A high-level representation of protein structure, the …

Bacterial conjugation is the fundamental process of unidirectional transfer of DNAs, often
plasmid DNAs, from a donor cell to a recipient cell. It is the primary means by which …