Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

In 1964, the psychoactive ingredient of Cannabis sativa, Δ 9-tetrahydrocannabinol (THC),
was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed …

There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …

The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

Human tissues express cannabinoid CB1 and CB2 receptors that can be activated by
endogenously released 'endocannabinoids' or exogenously administered compounds in a …

The mammalian body has a highly developed immune system which guards against
continuous invading protein attacks and aims at preventing, attenuating or repairing the …

Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

Cannabis sativa is best known as the source of marijuana, the world's most widely
consumed illicit recreational drug. However, the plant is also extremely useful as a source of …

Cannabinoids (CBs) from Cannabis sativa provide relief for tumor-associated symptoms
(including nausea, anorexia, and neuropathic pain) in the palliative treatment of cancer …

Cannabis sativa is also popularly known as marijuana. It has been cultivated and used by
man for recreational and medicinal purposes since many centuries. Study of cannabinoids …