The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …

Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …

We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a
highly aggressive acute leukaemia associated with poor clinical outcome. The preferential …

Recognition of histone covalent modifications by chromatin-binding protein modules ("
readers") constitutes a major mechanism for epigenetic regulation, typified by …

The recognition of modified histones by" reader" proteins constitutes a key mechanism
regulating gene expression in the chromatin context. Compared with the great variety of …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

Cancer cells are characterized by aberrant epigenetic landscapes and often exploit
chromatin machinery to activate oncogenic gene expression programs. Recognition of …

Regulation of the elongation phase of transcription by RNA polymerase II (Pol II) is utilized
extensively to generate the pattern of mRNAs needed to specify cell types and to respond to …

Elongation is becoming increasingly recognized as a critical step in eukaryotic
transcriptional regulation. Although traditional genetic and biochemical studies have …