Genome-wide association (GWA) studies have typically focused on the analysis of single
markers, which often lacks the power to uncover the relatively small effect sizes conferred by …

Dissecting the genetic architecture of complex traits is an ongoing challenge for geneticists.
Two complementary approaches for genetic mapping, linkage mapping and association …

Sequencing studies are increasingly being conducted to identify rare variants associated
with complex traits. The limited power of classical single-marker association analysis for rare …

High-throughput sequencing technology has enabled population-based studies of the role
of the human microbiome in disease etiology and exposure response. Distance-based …

GWAS have emerged as popular tools for identifying genetic variants that are associated
with disease risk. Standard analysis of a case-control GWAS involves assessing the …

The limitations of genome-wide association (GWA) studies that focus on the phenotypic
influence of common genetic variants have motivated human geneticists to consider the …

A large number of rare genetic variants have been discovered with the development in
sequencing technology and the lowering of sequencing costs. Rare variant analysis may …

In anticipation of the availability of next‐generation sequencing data, there is increasing
interest in investigating association between complex traits and rare variants (RVs). In …

Prediction of genetic values has been a focus of applied quantitative genetics since the
beginning of the 20th century, with renewed interest following the advent of the era of whole …

There is growing interest in performing genome-wide searches for associations between
genetic variants and brain imaging phenotypes. While much work has focused on single …