Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome

JS Knight, Y Kanthi - Seminars in immunopathology, 2022 - Springer
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia propelled by circulating
antiphospholipid antibodies that herald vascular thrombosis and obstetrical complications …

Thrombosis in systemic lupus erythematosus

A Palatinus, M Adams - Seminars in thrombosis and …, 2009 - thieme-connect.com
Systemic lupus erythematosus (SLE) is a potentially fatal multiorgan inflammatory disease
that primarily affects females. Due to the heterogeneity of clinical manifestations and lack of …

Hypercoagulability in chronic kidney disease is associated with coagulation activation but not endothelial function

MJ Adams, AB Irish, GF Watts, R Oostryck… - Thrombosis research, 2008 - Elsevier
INTRODUCTION: Patients with chronic kidney disease exhibit features of a hypercoagulable
state and have endothelial dysfunction, which may contribute to their increased …

What nephrologists need to know about antiphospholipid syndrome

B Alchi, M Griffiths, D Jayne - Nephrology Dialysis …, 2010 - academic.oup.com
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent
arterial or venous thrombosis and/or pregnancy losses, in the presence of persistently …

Decreased anticoagulant response to tissue factor pathway inhibitor type 1 in plasmas from patients with lupus anticoagulants

S Liestøl, PM Sandset, EM Jacobsen… - British journal of …, 2007 - Wiley Online Library
Inhibition of tissue factor pathway inhibitor type 1 (TFPI) is one of the mechanisms by which
lupus anticoagulants (LA) may upregulate tissue factor (TF) activity. We wanted to examine …

Thrombin generation and factor X assays for the assessment of warfarin anticoagulation in thrombotic antiphospholipid syndrome

M Efthymiou, AS Lawrie, I Mackie, D Arachchillage… - Thrombosis …, 2015 - Elsevier
Monitoring warfarin anticoagulation in patients with thrombotic antiphospholipid syndrome
(APS) may be complicated by the sensitivity of different thromboplastins to lupus …

Circulating biomarkers in chronic thromboembolic pulmonary hypertension

M Zhang, Y Zhang, W Pang, Z Zhai… - Pulmonary …, 2019 - journals.sagepub.com
Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition
characterized with chronic organized thrombi that obstruct the pulmonary vessels, leading to …

[PDF][PDF] Role of tissue factor in thrombosis. Coagulation-inflammation-thrombosis circuit

AJ Chu - Front Biosci, 2006 - article.imrpress.com
Introduction 3. Role of TF-initiated blood coagulation in thrombosis 4. Direct contribution to
thrombogenesis 4.1. Fibrin" thrombosis 4.2. Anti-fibrinolytic relevance 4.3. Platelet …

Antiphospholipid antibody-mediated thrombotic mechanisms in antiphospholipid syndrome: towards pathophysiology-based treatment

A Islam, F Alam, T Haryo Sasongko… - Current …, 2016 - ingentaconnect.com
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by a
persistently high titer of antiphospholipid antibodies (aPLs). In addition to pregnancy …

Antibodies against TFPI and protein C are associated with a severe thrombotic phenotype in patients with and without antiphospholipid syndrome

M Efthymiou, DRJ Arachchillage, PJ Lane… - Thrombosis …, 2018 - Elsevier
Background Tissue factor pathway inhibitor (TFPI) antibodies, which have been reported in
patients with antiphospholipid syndrome (APS), may impair TFPI activity and contribute to …