Time-of-day significantly influences the severity and incidence of stroke. Evidence has
emerged not only for circadian governance over stroke risk factors, but also for important …

Behavior and function of living systems are synchronized by the 24-h rotation of the Earth
that guides physiology according to time of day. However, when behavior becomes …

The circadian clock regulates daily rhythms of numerous physiological activities through
tightly coordinated modulation of gene expression and biochemical functions. Circadian …

The circadian clock of cyanobacteria, which predicts daily environmental changes, typically
includes a standard oscillator consisting of proteins KaiA, KaiB, and KaiC. However, several …

The healing of bone fractures can become aberrant and lead to nonunions which in turn
have a negative impact on patient health. Understanding why a bone fails to normally heal …

Despite the advancement in blood pressure (BP) lowering medications, uncontrolled
hypertension persists, underscoring a stagnation of effective clinical strategies. Novel and …

Circadian clocks have evolved to enable organisms to respond to daily environmental
changes. Maintaining a robust circadian rhythm under various perturbations and stresses is …

Melatonin, a versatile hormone produced by the pineal gland, has garnered considerable
scientific interest due to its diverse functions. In the eye, melatonin regulates a variety of key …

Background The treatment of metabolic system, cardiovascular system, and nervous system
diseases remains to be explored. In the internal environment of organisms, the metabolism …

Objective In this investigation, we addressed the contribution of the core circadian clock
factor, BMAL1, in skeletal muscle to both acute transcriptional responses to exercise and …