Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases
CG Schalkwijk, CDA Stehouwer - Physiological reviews, 2020 - journals.physiology.org
The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …
[HTML][HTML] The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality
Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and
peptides/proteins are an inevitable component of the aging process in all eukaryotic …
peptides/proteins are an inevitable component of the aging process in all eukaryotic …
Lipid and Carbohydrate Metabolism in Caenorhabditis elegans
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …
Regulation of pain and itch by TRP channels
Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …
pain perception. In this review, we discuss important experimental evidence involving some …
Cancer cells co-opt the neuronal redox-sensing channel TRPA1 to promote oxidative-stress tolerance
Cancer cell survival is dependent on oxidative-stress defenses against reactive oxygen
species (ROS) that accumulate during tumorigenesis. Here, we show a non-canonical …
species (ROS) that accumulate during tumorigenesis. Here, we show a non-canonical …
[HTML][HTML] Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 diabetes
A Moraru, J Wiederstein, D Pfaff, T Fleming, AK Miller… - Cell metabolism, 2018 - cell.com
The molecular causes of type 2 diabetes (T2D) are not well understood. Both type 1
diabetes (T1D) and T2D are characterized by impaired insulin signaling and hyperglycemia …
diabetes (T1D) and T2D are characterized by impaired insulin signaling and hyperglycemia …
Methylglyoxal metabolism and aging-related disease: moving from correlation toward causation
R Kold-Christensen, M Johannsen - Trends in Endocrinology & Metabolism, 2020 - cell.com
Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers
forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging …
forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging …
Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite
IP Heremans, F Caligiore, I Gerin… - Proceedings of the …, 2022 - National Acad Sciences
Cells are continuously exposed to potentially dangerous compounds. Progressive
accumulation of damage is suspected to contribute to neurodegenerative diseases and …
accumulation of damage is suspected to contribute to neurodegenerative diseases and …
Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience
Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …
Dysregulation of the mitochondrial unfolded protein response induces non-apoptotic dopaminergic neurodegeneration in C. elegans models of Parkinson's disease
BA Martinez, DA Petersen, AL Gaeta… - Journal of …, 2017 - Soc Neuroscience
Due to environmental insult or innate genetic deficiency, protein folding environments of the
mitochondrial matrix are prone to dysregulation, prompting the activation of a specific …
mitochondrial matrix are prone to dysregulation, prompting the activation of a specific …