Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …

Despite the success of antiretroviral therapy, human immunodeficiency virus (HIV) cannot be
cured because of a reservoir of latently infected cells that evades therapy. To understand the …

HIV-1 infection leads to a gradual loss of T helper cells, chronic immune activation, and
eventual immune system breakdown. HIV-1 causes deregulation of the expression of IL-2, a …

Human postmortem specimens are extremely valuable resources for investigating
translational hypotheses. Tissue repositories collect clinically assessed specimens from …

Genome wide association studies of isolated orofacial cleft (OFC) have identified common
single nucleotide polymorphisms (SNPs) at the 1q32/IRF6 locus and seven other loci where …

Transcription factor Ets-2 downregulates the expression of cytokine genes and HIV-1 in
resting T-cells. Herein, we studied whether Ets-2 regulates the expression of lymphotropic …

Background: RNase P-mediated cleavage of target RNAs has been proposed as a
promising tool for gene silencing. Ets-2 proto-oncogene controls the expression of a wide …

Abstract As of 2020, there were 37.7 million people living with Human Immunodeficiency
Virus type 1 (HIV-1). Although great strides have been made in treatment options for HIV-1 …

Despite the success of antiretroviral therapy, HIV cannot be cured because of a reservoir of
latently infected cells that evades therapy. To understand the mechanisms of HIV latency, we …

La proteina della leucemia promielocitica PML è essenziale per la formazione dei PML-NBs,
strutture nucleari che si formano tramite la separazione di due fasi liquide. La maggior parte …