[HTML][HTML] Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: From genes to functions

Ó Monroig, AC Shu-Chien, N Kabeya, DR Tocher… - Progress in lipid …, 2022 - Elsevier
Marine ecosystems are rich in “omega-3” long-chain (C 20-24) polyunsaturated fatty acids
(LC-PUFA). Their production has been historically accepted to derive mostly from marine …

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire

LFC Castro, DR Tocher, O Monroig - Progress in lipid research, 2016 - Elsevier
Long-chain polyunsaturated fatty acids (LC-PUFA) are major components of complex lipid
molecules and are also involved in numerous critical biological processes. Studies …

Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish

D Xie, C Chen, Y Dong, C You, S Wang… - Progress in Lipid …, 2021 - Elsevier
Abstract Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA, C 20-24),
including eicosapentaenoic acid (EPA, 20: 5n-3) and docosahexaenoic acid (DHA, 22: 6n …

Biosynthesis of polyunsaturated fatty acids in marine invertebrates: recent advances in molecular mechanisms

Ó Monroig, DR Tocher, JC Navarro - Marine drugs, 2013 - mdpi.com
Virtually all polyunsaturated fatty acids (PUFA) originate from primary producers but can be
modified by bioconversions as they pass up the food chain in a process termed trophic …

Novel cellular functions of very long chain-fatty acids: insight from ELOVL4 mutations

F Deák, RE Anderson, JL Fessler… - Frontiers in cellular …, 2019 - frontiersin.org
Elongation of Very Long chain fatty acids-4 (ELOVL4) protein is a member of the ELOVL
family of fatty acid elongases that is collectively responsible for catalyzing formation of long …

Very long chain fatty acids

L Kyselová, M Vítová, T Řezanka - Progress in lipid research, 2022 - Elsevier
Very long chain fatty acids (VLCFAs) are important components of various lipid classes in
most organisms, from bacteria to higher plants and mammals, including humans. VLCFAs …

[HTML][HTML] Two alternative pathways for docosahexaenoic acid (DHA, 22: 6n-3) biosynthesis are widespread among teleost fish

A Oboh, N Kabeya, G Carmona-Antoñanzas… - Scientific reports, 2017 - nature.com
Docosahexaenoic acid (DHA) plays important physiological roles in vertebrates. Studies in
rats and rainbow trout confirmed that DHA biosynthesis proceeds through the so-called …

Polyunsaturated fatty acid biosynthesis and metabolism in fish

O Monroig, DR Tocher, LFC Castro - Polyunsaturated fatty acid metabolism, 2018 - Elsevier
Fish are primary sources of the healthy n-3 long-chain polyunsaturated fatty acids (PUFA) for
humans. This also applied historically to farmed fish, but the impact that nonmarine …

CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target …

AK Datsomor, N Zic, K Li, RE Olsen, Y Jin, JO Vik… - Scientific reports, 2019 - nature.com
Atlantic salmon can synthesize polyunsaturated fatty acids (PUFAs), such as
eicosapentaenoic acid (20: 5n-3), arachidonic acid (20: 4n-6) and docosahexaenoic acid …

Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4

GK Yeboah, ES Lobanova, RS Brush… - Journal of Lipid Research, 2021 - ASBMB
Lipids play essential roles in maintaining cell structure and function by modulating
membrane fluidity and cell signaling. The fatty acid elongase-4 (ELOVL4) protein, expressed …