Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …

Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-
associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through …

Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs
and abundantly present in soluble egg antigen, has recently been shown to condition …

For the establishment of a successful infection, ie, long-term parasitism and a complete life
cycle, parasites use various diverse mechanisms and factors, which they may be inherently …

Parasitic helminths release molecules into their environment, which are generally referred to
as excretory-secretory products or ES. ES derived from a wide range of nematodes …

Exposure to commensal and pathogenic organisms strongly influences our immune system.
Exposure to helminths was frequent before humans constructed their current highly hygienic …

Developed countries are suffering from an epidemic rise in immunologic disorders, such as
allergy-related diseases and certain autoimmunities. Several studies have demonstrated a …

Helminths may protect humans against allergic and autoimmune diseases and, indeed,
defined helminth-derived products have recently been shown to prevent the development of …

Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which
induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby …

The classical reaction of the host to helminth infections is the induction of Th2 immune
responses with a regulatory component. DC, as central players in the induction and …