Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix
in the heart, providing support to the contracting myocardium and contributing to a myriad of …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular
matrix deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia …

The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes,
endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

Cardiac fibrosis is a substantial problem in managing multiple forms of heart disease.
Fibrosis results from an unrestrained tissue repair process orchestrated predominantly by …

Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

Rationale: Activated cardiac fibroblasts (CF) are crucial players in the cardiac damage
response; excess fibrosis, however, may result in myocardial stiffening and heart failure …

Cardiovascular tissue engineering aims to find solutions for the suboptimal regeneration of
heart valves, arteries and myocardium by creating 'living'tissue replacements outside (in …

Cardiac fibroblasts are the most populous nonmyocyte cell type within the mature heart and
are required for extracellular matrix synthesis and deposition, generation of the cardiac …