Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is
essential for the maintenance of mammalian water homeostasis. The vasopressin V2 …

The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

Simple Summary Connexin hemichannels are formed by connexin protein family members,
and connect cytosol and extracellular milium. The function of connexin hemichannels cannot …

The kidney is a remarkable organ that accomplishes the challenge of removing waste from
the body and simultaneously regulating electrolyte and water balance. Pro-urine flows …

Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called
connexins (Cxs) are major pathways for intercellular communication. While HCs connect the …

Hypertension is one of the most common risk factors for developing chronic cardiovascular
diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes …

In the process of mechanotransduction, the cells in the body perceive and interpret
mechanical stimuli to maintain tissue homeostasis and respond to the environmental …

Growing evidence suggests that glial cells express virtually all known types of
neurotransmitter receptors, enabling them to sense neuronal activity and microenvironment …

Neuronal activity must be tightly coordinated with blood flow to keep proper brain function,
which is achieved by a mechanism known as neurovascular coupling. Then, an increase in …

Intracellular ATP is the most vital source of cellular energy for biologic systems, whereas
extracellular ATP is a multifaceted mediator of several cell functions via its interaction, in an …