Objective To systematically review the efficacy of steroids in the prevention of acute
respiratory distress syndrome (ARDS) in critically ill adults, and treatment for established …

The systemic inflammatory response syndrome (SIRS) is an acute illness characterized by
generalized activation of the endothelium. The most severe form of the syndrome is found in …

Interleukin 1 receptor antagonist (IL-1ra) is a cytokine whose only known action is
competitive inhibition of the binding of interleukin 1 (IL-1) to its receptor. To investigate the …

Despite considerable progress, peritonitis and sepsis remain life-threatening conditions. To
improve the understanding of the pathophysiology encountered in sepsis, a new …

Objectives To determine whether the allele frequencies and genotype distribution of an
interleukin (IL)-1 beta TaqI polymorphism and an interleukin-1 receptor antagonist …

Intraamniotic infection is associated with increased IL-1 activity in amniotic fluid, increased
incidence of preterm labor, and with decreased incidence of respiratory distress syndrome in …

Fig. I. Proposed terminology of the septic process (systemic inflammatory response
syndrome) in children. In general, the risk of dying increases as one moves down the …

Since the discovery that epidermal cell-derived thymocyte-activating factor was identical to
interleukin (IL)-1α and-β in 1986, these molecules have been implicated in the pathogenesis …

Sepsis with acute organ dysfunction (severe sepsis) is common, frequently fatal, and
associated with a significant national health/economic burden. In addition to standard care …

The concept of multiple organ failure and related abnormalities was first developed in the
1970s. Multiple organ failure became evident when the support systems in intensive care …