Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

A central paradigm of immunity is that interferon (IFN)-mediated antiviral responses precede
pro-inflammatory ones, optimizing host protection and minimizing collateral damage,. Here …

The introduction and broad use of new immunosuppressive agents, including biologic
agents and JAK inhibitors, have revolutionised treatment of inflammatory bowel disease …

Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting …

Background Clinical trials of treatments for coronavirus disease 2019 (Covid-19) have not
shown a significant benefit of postexposure prophylaxis. Methods We conducted a phase 2 …

Co-infection has been reported in patients with severe acute respiratory syndrome (SARS)
and Middle East respiratory syndrome, but there is limited knowledge on co-infection among …

Methods| We used a random sample of 16 million patients (2006-2020) from the PharMetrics
Plus for Academics database (IQVIA), a large health claims database that captures 93% of …

Background: This document provides evidence-based clinical practice guidelines on the
management of adult patients with community-acquired pneumonia. Methods: A …