Advances and challenges in diagnostics of toxoplasmosis in HIV-infected patients

R Wesołowski, M Pawłowska, M Smoguła… - Pathogens, 2023 - mdpi.com
Toxoplasma gondii is a worldwide distributed protozoan parasite. This apicomplexan
parasite infects one-third of the population worldwide, causing toxoplasmosis, considered …

Key Limitations and New Insights Into the Toxoplasma gondii Parasite Stage Switching for Future Vaccine Development in Human, Livestock, and Cats

MN Mévélec, Z Lakhrif, I Dimier-Poisson - Frontiers in cellular and …, 2020 - frontiersin.org
Toxoplasmosis is a parasitic disease affecting human, livestock and cat. Prophylactic
strategies would be ideal to prevent infection. In a One Health vaccination approach, the …

Immunization with a novel mRNA vaccine, TGGT1_216200 mRNA-LNP, prolongs survival time in BALB/c mice against acute toxoplasmosis

Y Zhang, D Li, Y Shen, S Li, S Lu, B Zheng - Frontiers in Immunology, 2023 - frontiersin.org
Toxoplasma gondii, a specialized intracellular parasite, causes a widespread zoonotic
disease and is a severe threat to social and economic development. There is a lack of …

Immunomodulatory chitosan nanoparticles for Toxoplasma gondii infection: Novel application of chitosan in complex propranolol-hydrochloride as an adjuvant in …

Z Khorshidvand, S Shirian, H Amiri, A Zamani… - International Journal of …, 2023 - Elsevier
The study aimed to investigate the immunomodulatory effects of propranolol hydrochloride
(PRO) in combination with chitosan nanoparticles (CS NPs) as an adjuvant to develop an …

Toxoplasmosis vaccines: what we have and where to go?

Y Zhang, D Li, S Lu, B Zheng - npj Vaccines, 2022 - nature.com
Despite recent major advances in developing effective vaccines against toxoplasmosis,
finding new protective vaccination strategies remains a challenging and elusive goal as it is …

Protective efficacy by a novel multi-epitope vaccine, including MIC3, ROP8, and SAG1, against acute Toxoplasma gondii infection in BALB/c mice

S Dodangeh, M Fasihi-Ramandi, A Daryani… - Microbial …, 2021 - Elsevier
Toxoplasma gondii is an intracellular apicomplexan parasite, which can cause a serious
infectious disease in pregnant women and immunocompromised individuals. Therefore, the …

Multi-epitope vaccine expressed in Leishmania tarentolae confers protective immunity to Toxoplasma gondii in BALB/c mice

H Majidiani, A Dalimi, F Ghaffarifar, M Pirestani - Microbial Pathogenesis, 2021 - Elsevier
Current study deals with a novel multi-epitope vaccine designed in silico and its confirmation
experiments for potential efficacy in BALB/c mice. Major histocompatibility complex (MHC) …

Nano vaccines for T. gondii Ribosomal P2 Protein With Nanomaterials as a Promising DNA Vaccine Against Toxoplasmosis

ZQ Yu, K He, WD Cao, MT Aleem, RF Yan… - Frontiers in …, 2022 - frontiersin.org
Caused by Toxoplasma gondii, toxoplasmosis has aroused great threats to public health
around the world. So far, no effective vaccine or drug is commercially available, and the …

Immunogenicity of in-silico designed multi-epitope DNA vaccine encoding SAG1, SAG3 and SAG5 of Toxoplasma gondii adjuvanted with CpG-ODN against acute …

M Khodadadi, F Ghaffarifar, A Dalimi, E Ahmadpour - Acta Tropica, 2021 - Elsevier
The causative agent of toxoplasmosis, Toxoplasma gondii (T. gondii), is able to influence the
health of humans and other vertebrates. Toxoplasma may cause severe illness in the fetus …

A novel Toxoplasma gondii TGGT1_316290 mRNA-LNP vaccine elicits protective immune response against toxoplasmosis in mice

D Li, Y Zhang, S Li, B Zheng - Frontiers in Microbiology, 2023 - frontiersin.org
Toxoplasma gondii (T. gondii) can infect almost all warm-blooded animals and is a major
threat to global public health. Currently, there is no effective drug or vaccine for T. gondii. In …