Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

Health and nutritional risks co-occur in the lives of children under the age of 2 years who live
in developing countries. We review evidence showing how these risks, in addition to …

Background Seasonal malaria chemoprevention (SMC) aims to prevent malaria in children
during the high malaria transmission season. The Achieving Catalytic Expansion of SMC in …

Despite centuries of control efforts, mosquito-borne diseases are flourishing worldwide. With
a disproportionate effect on children and adolescents, these conditions are responsible for …

Background There is evidence that the age-pattern of Plasmodium falciparum malaria varies
with transmission intensity. A better understanding of how this varies with the severity of …

Background In 1993, Malawi became the first country in Africa to replace chloroquine with
the combination of sulfadoxine and pyrimethamine for the treatment of malaria. At that time …

Human co-infection with Plasmodium falciparum and helminths is ubiquitous throughout
Africa, although its public health significance remains a topic for which there are many …

Background Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine
(SP) plus amodiaquine (AQ), given each month during the transmission season, is …

Background Intermittent preventive treatment (IPT) is a promising strategy for malaria control
in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) …

Background Mass drug administration (MDA), defined as the empiric administration of a
therapeutic antimalarial regimen to an entire population at the same time, has been a …