Many mutations disappear from the population because they impair protein function and/or
stability. Thus, amino acid positions that are essential for proper function evolve more slowly …

Detergents are widely used for membrane protein solubilization, purification, and structural
analysis. Over the past two decades, much effort has been made to design novel detergents …

INTRODUCTION Protein homeostasis in the endoplasmic reticulum (ER) is maintained by a
quality control system. When a newly synthesized ER protein misfolds, it is ultimately …

A limiting factor in membrane protein research is the ability to solubilize and stabilize such
proteins. Detergents are used most often for solubilizing membrane proteins, but they are …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

There has been exponential growth in the number of membrane protein structures
determined. Nevertheless, these structures are usually resolved in the absence of their lipid …

Membrane protein biogenesis faces the challenge of chaperoning hydrophobic
transmembrane helices for faithful membrane insertion. The guided entry of tail-anchored …

The biotechnology industry has become a key element in modern societies. Within this
industry, the production of recombinant enzymes and biopharmaceutical proteins is of major …

Approximately 25% of eukaryotic genes code for integral membrane proteins that are
assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein …

Gram negative bacteria possess a large variety of protein transport systems, by which
proteins that are synthesised in the cytosol are exported to destinations in the cell envelope …