The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI)
tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including …

In the body, mucus provides an important defense mechanism by limiting the penetration of
pathogens. It is therefore also a major obstacle for the efficient delivery of particle-based …

Protective mucus coatings typically trap and rapidly remove foreign particles from the eyes,
gastrointestinal tract, airways, nasopharynx, and female reproductive tract, thereby strongly …

Mucus is a complex hydrogel, comprising glycoproteins, lipids, salts, DNA, enzymes and
cellular debris, covering many epithelial surfaces in the human body. Once secreted, mucin …

Pulmonary delivery of nanomedicines is very promising in lung local disease treatments
whereas several physiological barriers limit its application via the interaction with inhaled …

Gene therapy has emerged as an alternative for the treatment of diseases refractory to
conventional therapeutics. Synthetic nanoparticle-based gene delivery systems offer highly …

Cystic fibrosis (CF) is a monogenic autosomal recessive disorder that affects about 70 000
people worldwide. The clinical manifestations of the disease are caused by defects in the …

Mucus can effectively protect the exposed mucosal surfaces due to its adhesive and
viscoelastic properties. Most foreign particulates are efficiently trapped in mucus layers via …

Current biochemical characterizations of cystic fibrosis (CF) sputum do not address the high
degree of microheterogeneity in the rheological properties of the mucosal matrix and only …