Amino assets: how amino acids support immunity
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …
is well defined, but they contribute to a host of other intracellular metabolic pathways …
Macrophage polarization: different gene signatures in M1 (LPS+) vs. classically and M2 (LPS–) vs. alternatively activated macrophages
M Orecchioni, Y Ghosheh, AB Pramod… - Frontiers in …, 2019 - frontiersin.org
Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue
macrophages are seeded in the early embryo before definitive hematopoiesis is …
macrophages are seeded in the early embryo before definitive hematopoiesis is …
Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
R Missiaen, NM Anderson, LC Kim, B Nance… - Cell metabolism, 2022 - cell.com
Hepatocellular carcinoma (HCC) is a typically fatal malignancy exhibiting genetic
heterogeneity and limited therapy responses. We demonstrate here that HCCs consistently …
heterogeneity and limited therapy responses. We demonstrate here that HCCs consistently …
Programmed cell death ligand 1 (PD-L1) signaling regulates macrophage proliferation and activation
Tumor-associated macrophages (TAMs) express programmed cell death ligand 1 (PD-L1)
and contribute to the immune-suppressive tumor microenvironment. Although the role of the …
and contribute to the immune-suppressive tumor microenvironment. Although the role of the …
Metabolic modulation in macrophage effector function
C Diskin, EM Pålsson-McDermott - Frontiers in immunology, 2018 - frontiersin.org
Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic
pathways generating energy and biosynthetic precursors required for growth and general …
pathways generating energy and biosynthetic precursors required for growth and general …
Heterogeneity of microglial activation in the innate immune response in the brain
CA Colton - Journal of neuroimmune pharmacology, 2009 - Springer
The immune response in the brain has been widely investigated and while many studies
have focused on the proinflammatory cytotoxic response, the brain's innate immune system …
have focused on the proinflammatory cytotoxic response, the brain's innate immune system …
Arginine and citrulline and the immune response in sepsis
KAP Wijnands, TMR Castermans, MPJ Hommen… - Nutrients, 2015 - mdpi.com
Arginine, a semi-essential amino acid is an important initiator of the immune response.
Arginine serves as a precursor in several metabolic pathways in different organs. In the …
Arginine serves as a precursor in several metabolic pathways in different organs. In the …
[HTML][HTML] Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration
Purpose Our objective was to comprehensively assess the nature and chronology of neural
remodeling in retinal degenerations triggered by light-induced retinal damage (LIRD) in …
remodeling in retinal degenerations triggered by light-induced retinal damage (LIRD) in …
Tumor-associated macrophages (TAMs): a critical activator in ovarian cancer metastasis
M Yin, J Shen, S Yu, J Fei, X Zhu, J Zhao… - OncoTargets and …, 2019 - Taylor & Francis
Tumor-associated macrophages (TAMs) that appear in every stage of cancer progression
are usually tumor-promoting cells and are present abundantly in the tumor-associated …
are usually tumor-promoting cells and are present abundantly in the tumor-associated …