Coumarin derivatives are important class of natural plant metabolites that offer variety of
biological activities. They can also be derived synthetically, and a wide variety of synthetic …

Heading the list of the critical health-related issues worldwide, cancer continues to be a one
of the most serious life-threatening diseases. The rate of cancer-related mortality is at …

Cancer is the second leading cause of death worldwide, and it results in around 9 million
deaths annually. The anticancer agents play an intriguing role in the treatment of cancers …

Many researchers around the world are working on the development of novel anticancer
drugs with different mechanisms of action. In this case, coumarin is a highly promising …

Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …

Considering highly valuable biological and pharmaceutical properties of coumarins, the
synthesis of these heterocycles has been considered for many organic and pharmaceutical …

The cancer cases are increasing in fast pace; most of them are resulted from exposure to
harmful pollutants. Genetic factors are responsible for cancer only to a small extent …

The structural motif of coumarins is related with various biological activities and
pharmacological properties. Both natural coumarin extracted from various plants or a new …

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans,
and a current and promising inhibition target for the development of new chemosensitizing …

In this study, a new isoxazoline derived from acridone, 10‐{[3‐(4‐chlorophenyl)‐4, 5‐
dihydro‐1, 2‐oxazol‐5 yl] methyl} acridone (3) was successfully synthesized and …