Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …

Nonalcoholic fatty liver disease (NAFLD) is common in the elderly, in whom it carries a more
substantial burden of hepatic (nonalcoholic steatohepatitis, cirrhosis and hepatocellular …

This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …

The human gut microbiome has been linked to numerous digestive disorders, but its
metabolic products have been much less well characterized, in part due to the expense of …

Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile
acids, in addition to providing structure to cell membranes. Whole body cholesterol …

Bile acids (BAs) are essential for fat absorption and appear to modulate glucose and energy
metabolism. Colesevelam, a BA sequestrant, improves glycemic control in type 2 diabetes …

In humans, aging, triggers increased plasma concentrations of triglycerides, cholesterol, low-
density lipoproteins and lower capacity of high-density lipoproteins to remove cellular …

Drug-metabolizing enzymes (DMEs) and membrane transporters play important roles in the
absorption, distribution, metabolism, and excretion processes that determine the …

Regulation of bile acid metabolism is normally discussed as the regulation of bile acid
synthesis, which serves to compensate for intestinal loss in order to maintain a constant pool …

Lipid metabolism plays crucial roles in cellular processes such as hormone synthesis,
energy production, and fat storage. Older adults are at risk of the dysregulation of lipid …