Edema, hyperalgesia and myonecrosis induced by Brazilian bothropic venoms: Overview of the last decade

CCN Mamede, BB de Sousa Simamoto… - Toxicon, 2020 - Elsevier
Snakebite accidents are considered serious public health problems. They are often
neglected, and individuals who have received insufficient treatment are subjected to various …

Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology

JS Cavalcante, DEG de Almeida… - International Journal of …, 2023 - mdpi.com
Snakebite envenoming represents a major health problem in tropical and subtropical
countries. Considering the elevated number of accidents and high morbidity and mortality …

The role of platelets in hemostasis and the effects of snake venom toxins on platelet function

MR de Queiroz, BB de Sousa, DF da Cunha Pereira… - Toxicon, 2017 - Elsevier
The human body has a set of physiological processes, known as hemostasis, which keeps
the blood fluid and free of clots in normal vessels; in the case of vascular injury, this process …

Human breast cancer cell death induced by BnSP-6, a Lys-49 PLA2 homologue from Bothrops pauloensis venom

FVPV Azevedo, DS Lopes, SNC Gimenes… - International journal of …, 2016 - Elsevier
This work shows the antitumoral effects of BnSP-6, a Lys 49 PLA 2 isolated from Bothrops
pauloensis venom, on human breast cancer MDA-MB-231 cells. BnSP-6 caused a dose …

Acute Kidney Injury Induced by Bothrops Venom: Insights into the Pathogenic Mechanisms

PLMM Albuquerque, GB da Silva Junior, GC Meneses… - Toxins, 2019 - mdpi.com
Acute kidney injury (AKI) following snakebite is common in developing countries and
Bothrops genus is the main group of snakes in Latin America. To evaluate the pathogenic …

State-of-the-art review-A review on snake venom-derived antithrombotics: Potential therapeutics for COVID-19-associated thrombosis?

B Kalita, AJ Saviola, SP Samuel… - International Journal of …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent
responsible for the Coronavirus Disease-2019 (COVID-19) pandemic, has infected over 185 …

Effects of cilostazol, a Phosphodiesterase-3 inhibitor, on kidney function and redox imbalance in acute kidney injury caused by Bothrops alternatus venom

AD Marinho, ARC Jorge, FAN Junior… - Toxicon, 2022 - Elsevier
The mechanisms of pathogenesis of acute kidney injury (AKI) in snakebites is multifactorial
and involves hemodynamic disturbances, with release of free radical causing cytotoxic …

[HTML][HTML] Purification procedure for the isolation of a PI metalloprotease and an acidic phospholipase A 2 fromBothrops atrox snake venom

DL Menaldo, AL Jacob-Ferreira… - Journal of Venomous …, 2015 - SciELO Brasil
Background Snake venoms are complex mixtures of inorganic and organic components,
mainly proteins and peptides. Standardization of methods for isolating bioactive molecules …

Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2

LL Casais-e-Silva, CFP Teixeira, I Lebrun, B Lomonte… - Toxicology letters, 2016 - Elsevier
The venom of Micrurus lemniscatus, a coral snake of wide geographical distribution in South
America, was fractionated by reverse-phase HPLC and the fractions screened for …

[HTML][HTML] Partial in vitro analysis of toxic and antigenic activities of eleven Peruvian pitviper snake venoms

C Guerra-Duarte, J Lopes-Peixoto… - Toxicon, 2015 - Elsevier
This work used eleven Peruvian snake venoms (Bothrops andianus, Bothrops atrox,
Bothrops barnetti, Bothrops castelnaudi, Bothriopsis chloromelas, Bothrocophias …