[HTML][HTML] In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial
I Gurevich, P Agarwal, PP Zhang, JA Dolorito… - Nature Medicine, 2022 - nature.com
Recessive dystrophic epidermolysis bullosa (RDEB) is a lifelong genodermatosis
associated with blistering, wounding, and scarring caused by mutations in COL7A1, the …
associated with blistering, wounding, and scarring caused by mutations in COL7A1, the …
Current knowledge of immunomodulation strategies for chronic skin wound repair
In orchestrating the wound healing process, the immune system plays a critical role. Hence,
controlling the immune system to repair skin defects is an attractive approach. The highly …
controlling the immune system to repair skin defects is an attractive approach. The highly …
Birch bark extract: a review in epidermolysis bullosa
YA Heo - Drugs, 2023 - Springer
Birch bark extract (Filsuvez®; also known as the developmental name Oleogel-S10), a
topical gel consisting of 10% dry birch bark extract and 90% sunflower oil, is the first therapy …
topical gel consisting of 10% dry birch bark extract and 90% sunflower oil, is the first therapy …
[HTML][HTML] A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa
G Neumayer, JL Torkelson, S Li, K McCarthy… - Nature …, 2024 - nature.com
Abstract We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable
platform producing autologous organotypic iPS cell-derived induced skin composite (iSC) …
platform producing autologous organotypic iPS cell-derived induced skin composite (iSC) …
[HTML][HTML] Long-term safety and efficacy of gene-corrected autologous keratinocyte grafts for recessive dystrophic epidermolysis bullosa
JY So, J Nazaroff, CV Iwummadu, N Harris… - Orphanet Journal of …, 2022 - Springer
Background Recessive dystrophic epidermolysis bullosa (RDEB) is a rare, devastating
blistering genodermatosis caused by mutations in the COL7A1 gene, which encodes for …
blistering genodermatosis caused by mutations in the COL7A1 gene, which encodes for …
[HTML][HTML] Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine
E Niebergall-Roth, NY Frank, C Ganss… - International Journal of …, 2022 - mdpi.com
The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident
mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing …
mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing …
Emerging gene therapeutics for Epidermolysis Bullosa under Development
The monogenetic disease epidermolysis bullosa (EB) is characterised by the formation of
extended blisters and lesions on the patient's skin upon minimal mechanical stress. Causal …
extended blisters and lesions on the patient's skin upon minimal mechanical stress. Causal …
[HTML][HTML] Multidisciplinary care for patients with epidermolysis bullosa from birth to adolescence: experience of one Italian reference center
C Retrosi, A Diociaiuti, C De Ranieri… - Italian Journal of …, 2022 - Springer
Background Epidermolysis bullosa (EB) is a disabling and chronic genodermatosis
characterized by mucocutaneous fragility with blister formation after minimal trauma …
characterized by mucocutaneous fragility with blister formation after minimal trauma …
Stairways to advanced therapies for epidermolysis bullosa
L De Rosa, E Enzo, M Palamenghi… - Cold Spring …, 2023 - cshperspectives.cshlp.org
Epidermolysis bullosa (EB) is a devastating genetic skin disease typified by a plethora of
different phenotypes and ranking from severe, early lethal, to mild localized forms. Although …
different phenotypes and ranking from severe, early lethal, to mild localized forms. Although …
Beyond the surface: a narrative review examining the systemic impacts of recessive dystrophic epidermolysis bullosa
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic disease resulting from
inadequate type VII collagen (C7). Although recurrent skin blisters and wounds are the most …
inadequate type VII collagen (C7). Although recurrent skin blisters and wounds are the most …