[HTML][HTML] In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial

I Gurevich, P Agarwal, PP Zhang, JA Dolorito… - Nature Medicine, 2022 - nature.com
Recessive dystrophic epidermolysis bullosa (RDEB) is a lifelong genodermatosis
associated with blistering, wounding, and scarring caused by mutations in COL7A1, the …

Current knowledge of immunomodulation strategies for chronic skin wound repair

P Heydari, M Kharaziha, J Varshosaz… - … Research Part B …, 2022 - Wiley Online Library
In orchestrating the wound healing process, the immune system plays a critical role. Hence,
controlling the immune system to repair skin defects is an attractive approach. The highly …

Birch bark extract: a review in epidermolysis bullosa

YA Heo - Drugs, 2023 - Springer
Birch bark extract (Filsuvez®; also known as the developmental name Oleogel-S10), a
topical gel consisting of 10% dry birch bark extract and 90% sunflower oil, is the first therapy …

[HTML][HTML] A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa

G Neumayer, JL Torkelson, S Li, K McCarthy… - Nature …, 2024 - nature.com
Abstract We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable
platform producing autologous organotypic iPS cell-derived induced skin composite (iSC) …

[HTML][HTML] Long-term safety and efficacy of gene-corrected autologous keratinocyte grafts for recessive dystrophic epidermolysis bullosa

JY So, J Nazaroff, CV Iwummadu, N Harris… - Orphanet Journal of …, 2022 - Springer
Background Recessive dystrophic epidermolysis bullosa (RDEB) is a rare, devastating
blistering genodermatosis caused by mutations in the COL7A1 gene, which encodes for …

[HTML][HTML] Skin-Derived ABCB5+ Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine

E Niebergall-Roth, NY Frank, C Ganss… - International Journal of …, 2022 - mdpi.com
The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident
mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing …

Emerging gene therapeutics for Epidermolysis Bullosa under Development

J Bischof, M Hierl, U Koller - International Journal of Molecular Sciences, 2024 - mdpi.com
The monogenetic disease epidermolysis bullosa (EB) is characterised by the formation of
extended blisters and lesions on the patient's skin upon minimal mechanical stress. Causal …

[HTML][HTML] Multidisciplinary care for patients with epidermolysis bullosa from birth to adolescence: experience of one Italian reference center

C Retrosi, A Diociaiuti, C De Ranieri… - Italian Journal of …, 2022 - Springer
Background Epidermolysis bullosa (EB) is a disabling and chronic genodermatosis
characterized by mucocutaneous fragility with blister formation after minimal trauma …

Stairways to advanced therapies for epidermolysis bullosa

L De Rosa, E Enzo, M Palamenghi… - Cold Spring …, 2023 - cshperspectives.cshlp.org
Epidermolysis bullosa (EB) is a devastating genetic skin disease typified by a plethora of
different phenotypes and ranking from severe, early lethal, to mild localized forms. Although …

Beyond the surface: a narrative review examining the systemic impacts of recessive dystrophic epidermolysis bullosa

C Popp, W Miller, C Eide, J Tolar, JA McGrath… - Journal of Investigative …, 2024 - Elsevier
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic disease resulting from
inadequate type VII collagen (C7). Although recurrent skin blisters and wounds are the most …