Leishmaniasis: current status of available drugs and new potential drug targets

N Singh, M Kumar, RK Singh - Asian Pacific journal of tropical medicine, 2012 - Elsevier
The control of Leishmania infection relies primarily on chemotherapy till date. Resistance to
pentavalent antimonials, which have been the recommended drugs to treat cutaneous and …

Leishmania treatment and prevention: Natural and synthesized drugs

AA Bekhit, E El-Agroudy, A Helmy, TM Ibrahim… - European journal of …, 2018 - Elsevier
Leishmaniasis affects over 150 million people all over the world, especially in subtropical
regions. Currently used antileishmanial synthesized drugs are associated with some …

[图书][B] Therapeutic and nutritional uses of algae

L Pereira - 2018 - taylorfrancis.com
Algae have been used since ancient times as food, fodder, fertilizer and as source of
medicine. Nowadays seaweeds represent an unlimited source of the raw materials used in …

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

JL Siqueira-Neto, S Moon, J Jang, G Yang… - PLoS neglected …, 2012 - journals.plos.org
Leishmaniasis is a tropical disease threatening 350 million people from endemic regions.
The available drugs for treatment are inadequate, with limitations such as serious side …

[HTML][HTML] New drugs with antiprotozoal activity from marine algae: a review

FAE Torres, TG Passalacqua, A Velásquez… - Revista Brasileira de …, 2014 - SciELO Brasil
The use of indigenous or remote popular knowledge to identify new drugs against diseases
or infections is a well-known approach in medicine. The inhabitants of coastal regions are …

[HTML][HTML] Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis

D Caridha, B Vesely, K van Bocxlaer, B Arana… - International Journal for …, 2019 - Elsevier
Although there have been significant advances in the treatment of visceral leishmaniasis
(VL) and several novel compounds are currently in pre-clinical and clinical development for …

A review: the current in vivo models for the discovery and utility of new anti-leishmanial drugs targeting cutaneous leishmaniasis

ER Mears, F Modabber, R Don… - PLoS neglected tropical …, 2015 - journals.plos.org
The current in vivo models for the utility and discovery of new potential anti-leishmanial
drugs targeting Cutaneous Leishmaniasis (CL) differ vastly in their immunological …

Host‐Parasite Interaction: Parasite‐Derived and‐Induced Proteases That Degrade Human Extracellular Matrix

C Piña-Vázquez, M Reyes-López… - Journal of …, 2012 - Wiley Online Library
Parasitic protozoa are among the most important pathogens worldwide. Diseases such as
malaria, leishmaniasis, amoebiasis, giardiasis, trichomoniasis, and trypanosomiasis affect …

Improvement of the green fluorescent protein reporter system in Leishmania spp. for the in vitro and in vivo screening of antileishmanial drugs

SA Pulido, DL Munoz, AM Restrepo, CV Mesa… - Acta tropica, 2012 - Elsevier
Development of new therapeutic approaches for leishmaniasis treatment requires new high
throughput screening methodologies for the antileishmanial activity of the new compounds …

Infrared Fluorescent Imaging as a Potent Tool for In Vitro, Ex Vivo and In Vivo Models of Visceral Leishmaniasis

E Calvo-Alvarez, K Stamatakis, C Punzón… - PLoS neglected …, 2015 - journals.plos.org
Background Visceral leishmaniasis (VL) is hypoendemic in the Mediterranean region, where
it is caused by the protozoan Leishmania infantum. An effective vaccine for humans is not …