lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …

The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …

Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus
(DM), which can lead to renal failure in diabetic patients. At present, the first-line drugs for …

TGF-β1–induced expression of extracellular matrix (ECM) genes plays a major role in the
development of chronic renal diseases such as diabetic nephropathy. Although many key …

Introduction: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and is
considered to be a sterile inflammatory disease. Increasing evidence suggest that pyroptosis …

Long noncoding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been reported to play
a key role in the progression of diabetic nephropathy (DN). However, the role of lncRNA …

Diabetic nephropathy (DN) is characterized by mesangial cell (MC) expansion and
accumulation of extracellular matrix proteins. TGF-β is increased in MC under diabetic …

Small lipids such as eicosanoids exert diverse and complex functions. In addition to their
role in regulating normal kidney function, these lipids also play important roles in the …

Due to the incidence of type-2 diabetes and hypertension, chronic kidney disease (CKD)
has emerged as a major public health problem worldwide. CKD results in premature death …

Hyperlipidemia is a major risk factor for coronary heart disease and has emerged as an
important public health problem. Lipidomics is a powerful technology for assessment of …