Centrosomes are the main microtubule-organizing centre of animal cells and are important
for many critical cellular and developmental processes from cell polarization to cell division …

Each time a cell divides its chromosome content must be equally segregated into the two
daughter cells. This critical process is mediated by a complex microtubule based apparatus …

Inducible degradation is a powerful approach for identifying the function of a specific protein
or protein complex. Recently, a plant auxin-inducible degron (AID) system has been shown …

Centrosome amplification is a hallmark of human tumours. In flies, extra centrosomes cause
spindle position defects that result in the expansion of the neural stem cell (NSC) pool and …

Centrioles are essential for ciliogenesis. However, mutations in centriole biogenesis genes
have been reported in primary microcephaly and Seckel syndrome, disorders without the …

Centriole function has been difficult to study because of a lack of specific tools that allow
persistent and reversible centriole depletion. Here we combined gene targeting with an …

Centrioles organize the centrosome, and accurate control of their number is critical for the
maintenance of genomic integrity. Centriole duplication occurs once per cell cycle and is …

Centrosomes are microtubule-organizing centers that facilitate bipolar mitotic spindle
assembly and chromosome segregation. Recognizing that centrosome amplification is a …

Purpose Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase that regulates
centriole duplication. PLK4 deregulation causes centrosome number abnormalities, mitotic …

Centrosome amplification, the presence of more than two centrosomes in a cell is a common
feature of most human cancer cell lines. However, little is known about centrosome numbers …