As a main digestive organ and an important immune organ, the intestine plays a vital role in
resisting the invasion of potential pathogens into the body. Intestinal immune dysfunction …

Ovarian cancer (OC) is one of the most common malignancies that causes death in women
and is a heterogeneous disease with complex molecular and genetic changes. Because of …

Current natural killer (NK) cell-based cancer immunotherapy for the treatment of solid tumors
often exhibits insufficient cancer recognition specificity, thereby limiting therapeutic …

Background: Necroptosis is closely related to the tumorigenesis and development of cancer.
An increasing number of studies have demonstrated that targeting necroptosis could be a …

Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the gastrointestinal tract,
while the present therapeutic efficacy is insufficient. In recent years, numerous studies have …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint destruction,
synovitis, and pannus formation. Gut microbiota dysbiosis may exert direct pathogenic …

Disruption of the intestinal epithelial barrier is a hallmark of mucosal inflammation. It
increases exposure of the immune system to luminal microbes, triggering a perpetuating …

Background Patient-derived organoid (PDO) models offer potential to transform drug
discovery for inflammatory bowel disease (IBD) but are limited by inconsistencies with …

Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease driven by
bacterial colonization of colonic intestinal epithelial cells. Vertebrates have evolved …

The elevated level of interferon-γ (IFN-γ) in Sjogren's syndrome (SS) triggers salivary gland
epithelial cells (SGEC) death. However, the underlying mechanisms of IFN-γ-induced SGEC …