Management of urinary incontinence in postmenopausal women: An EMAS clinical guide

E Russo, M Caretto, A Giannini, J Bitzer, A Cano… - Maturitas, 2021 - Elsevier
Introduction The prevalence of urinary incontinence and of other lower urinary tract
symptoms increases after the menopause and affects between 38% and 55% of women …

Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction

LA Birder, EK Jackson - Nature Reviews Urology, 2022 - nature.com
The lower urinary tract (LUT), including the bladder, urethra and external striated muscle,
becomes dysfunctional with age; consequently, many older individuals suffer from lower …

Hypoxanthine induces signs of bladder aging with voiding dysfunction and lower urinary tract remodeling

LA Birder, AS Wolf-Johnston… - The Journals of …, 2024 - academic.oup.com
Background Lower urinary tract syndrome (LUTS) is a group of urinary tract symptoms and
signs that can include urinary incontinence. Advancing age is a major risk factor for LUTS; …

[HTML][HTML] Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions

LA Birder, A Wolf-Johnston, AJ Wein, F Cheng… - JCI insight, 2020 - ncbi.nlm.nih.gov
In the aging population, lower urinary tract (LUT) dysfunction is common and often leads to
storage and voiding difficulties classified into overlapping symptom syndromes. Despite …

A 10-to 20-year follow-up after tension-free vaginal tape for stress urinary incontinence

EMV Goessens, H Cammu - International Urogynecology Journal, 2023 - Springer
Introduction and hypothesis Midurethral slings (MUS) have become the gold standard in the
treatment of stress urinary incontinence (SUI). Some information is already available on the …

Treating overactive bladder in older patients with a combination of mirabegron and solifenacin: a prespecified analysis from the BESIDE study

W Gibson, S MacDiarmid, M Huang, E Siddiqui… - European Urology …, 2017 - Elsevier
Background The BESIDE study demonstrated that combination therapy (mirabegron and
solifenacin 5 mg) improved overactive bladder symptoms versus solifenacin 5 mg or 10 mg …

The brain, gut, and bladder health nexus: A conceptual model linking stress and mental health disorders to overactive bladder in women

AL Smith, A Berry, L Brubaker… - Neurourology and …, 2024 - Wiley Online Library
Objective A small, but growing literature links stressors and mental health disorders (MHDs)
across the life course to overactive bladder (OAB) and urinary incontinence symptoms …

Mirabegron in the treatment of overactive bladder: safety and efficacy in the very elderly patient

A Makhani, M Thake, W Gibson - Clinical interventions in aging, 2020 - Taylor & Francis
Lower urinary tract symptoms, including urgency, urgency incontinence, frequency, and
nocturia, are highly prevalent in older adults and are associated with significant morbidity …

Pad test for urinary incontinence diagnosis in adults: Systematic review of diagnostic test accuracy

C Medeiros Araujo, NR de Morais… - Neurourology and …, 2022 - Wiley Online Library
Introduction The pad test is an assessment tool for urinary incontinence (UI) severity
classification and therapeutic response monitoring. However, the reliability and …

[HTML][HTML] Aging-associated changes in oxidative stress negatively impacts the urinary bladder urothelium

MM de Rijk, A Wolf-Johnston, AF Kullmann… - International …, 2022 - ncbi.nlm.nih.gov
Purpose Lower urinary tract symptoms are known to significantly increase with age,
negatively impacting quality of life and self-reliance. The urothelium fulfills crucial tasks …