Peptidomimetic toolbox for drug discovery
E Lenci, A Trabocchi - Chemical Society Reviews, 2020 - pubs.rsc.org
The art of transforming peptides into drug leads is still a dynamic and fertile field in medicinal
chemistry and drug discovery. Peptidomimetics can respond to peptide limitations by …
chemistry and drug discovery. Peptidomimetics can respond to peptide limitations by …
Protein-mimetic peptide nanofibers: Motif design, self-assembly synthesis, and sequence-specific biomedical applications
The design and fabrication of self-assembled peptide nanostructures offer an amazing
platform for creating functional nanomaterials for various biomedical applications. Utilizing …
platform for creating functional nanomaterials for various biomedical applications. Utilizing …
[图书][B] The organic chemistry of drug design and drug action
RB Silverman, MW Holladay - 2014 - books.google.com
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique
approach to medicinal chemistry based on physical organic chemical principles and …
approach to medicinal chemistry based on physical organic chemical principles and …
A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site
M Nabeno, F Akahoshi, H Kishida, I Miyaguchi… - Biochemical and …, 2013 - Elsevier
In recent years, various dipeptidyl peptidase IV (DPP-4) inhibitors have been released as
therapeutic drugs for type 2 diabetes in many countries. In spite of their diverse chemical …
therapeutic drugs for type 2 diabetes in many countries. In spite of their diverse chemical …
Peptidomimetics—tailored enzyme inhibitors
J Gante - Angewandte Chemie International Edition in English, 1994 - Wiley Online Library
Peptides and proteins (there is no clear boundary between the two classes of compounds)
are absolutely essential components of organisms in many ways. While proteins have …
are absolutely essential components of organisms in many ways. While proteins have …
Scaffold hopping
HJ Böhm, A Flohr, M Stahl - Drug discovery today: Technologies, 2004 - Elsevier
The aim of scaffold hopping is to discover structurally novel compounds starting from known
active compounds by modifying the central core structure of the molecule. Scaffold hopping …
active compounds by modifying the central core structure of the molecule. Scaffold hopping …
Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics
S Hanessian, G McNaughton-Smith, HG Lombart… - Tetrahedron, 1997 - Elsevier
The field of amino acids has gained enormous popularity and relevance in recent years,
particularly with the emergence of unnatural analogs as components of molecules with …
particularly with the emergence of unnatural analogs as components of molecules with …
Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies
Clinical development of orally active peptide drugs has been restricted by their unfavorable
physicochemical properties, which limit their intestinal mucosal permeation and their lack of …
physicochemical properties, which limit their intestinal mucosal permeation and their lack of …
Templates that Induce. Alpha.-helical,. Beta.-sheet, and loop conformations
JP Schneider, JW Kelly - Chemical reviews, 1995 - ACS Publications
Polypeptides composed of 30 amino acid residues or less typically do not adoptwell-defined
conformations in aqueous solution; rather they adopt an ensemble of energetically similar …
conformations in aqueous solution; rather they adopt an ensemble of energetically similar …
[PDF][PDF] Comparative quantitative structure− activity relationship studies on anti-HIV drugs
R Garg, SP Gupta, H Gao, MS Babu… - Chemical …, 1999 - researchgate.net
In the present era, acquired immunodeficiency syndrome (AIDS) is the most fatal disorder for
which no completely successful chemotherapy has been developed so far. The pandemic …
which no completely successful chemotherapy has been developed so far. The pandemic …