Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

The mechanism that initiates autophagosome formation on the ER in multicellular organisms
is elusive. Here, we showed that autophagy stimuli trigger Ca 2+ transients on the outer …

INTRODUCTION Macroautophagy (hereafter autophagy) is an evolutionarily conserved
lysosomal degradation pathway. It ensures cellular homeostasis and health by removing …

Autophagy contributes to the selective degradation of liquid droplets, including the P-
Granule, Ape1-complex and p62/SQSTM1-body, although the molecular mechanisms and …

The field of autophagy research has developed rapidly since the first description of the
process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is …

Autophagy is a powerful tool that host cells use to defend against viral infection. Double-
membrane vesicles, termed autophagosomes, deliver trapped viral cargo to the lysosome …