Targeted protein degradation: advances, challenges, and prospects for computational methods

B Mostofian, HJ Martin, A Razavi, S Patel… - Journal of Chemical …, 2023 - ACS Publications
The therapeutic approach of targeted protein degradation (TPD) is gaining momentum due
to its potentially superior effects compared with protein inhibition. Recent advancements in …

Degraders upgraded: the rise of PROTACs in hematological malignancies

JML Casan, JF Seymour - Blood, 2024 - ashpublications.org
Targeted protein degradation (TPD) is a revolutionary approach to targeted therapy in
hematological malignancies that potentially circumvents many constraints of existing small …

[HTML][HTML] Advances in designing ternary complexes: Integrating in-silico and biochemical methods for PROTAC optimisation in target protein degradation

S Shaik, PKR Gayam, M Chaudhary, G Singh, A Pai - Bioorganic Chemistry, 2024 - Elsevier
Target protein degradation (TPD) is an emerging approach to mitigate disease-causing
proteins. TPD contains several strategies, and one of the strategies that gained immersive …