Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and
skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a …

Cancer-related anemia (CRA) is a common sign occurring in more than 30% of cancer
patients at diagnosis before the initiation of antineoplastic therapy. CRA has a relevant …

Objective Accumulation of myofibroblasts in fibrotic skin is a hallmark of systemic sclerosis
(SSc; scleroderma), but the origins of these cells remain unknown. Because loss of …

Background and aim Clinical evidence which investigated the effects of l-carnitine, a vitamin-
like substance, on weight loss had led to inconsistent results. This study therefore aimed to …

The past few years have provided substantial evidence for the vital role of the local tumor
microenvironment for various aspects of tumor progression. With obesity and its …

Abstract Cytochrome P450 2E1 (CYP2E1) is suggested to play a role in alcoholic liver
disease, which includes alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis. In …

Cachexia has a devastating impact on survival and quality of life for many cancer patients. A
better understanding of the underlying mechanisms leading to the complex metabolic …

CONTEXT: In pancreatic cancer, the presence of obesity or weight loss is associated with
higher mortality. OBJECTIVES: To explore the relationships among body mass index …

Macrophage inhibitory cytokine-1 (MIC-1), a divergent member of the TGF-β superfamily, is
involved in the control of multiple cellular processes and mediates cachexia through the …

In this review we introduce the concept of the tumor macroenvironment and explore it in the
context of metabolism. Tumor cells interact with the tumor microenvironment including …