Collagen-and hyaluronic acid-based hydrogels and their biomedical applications
Hydrogels have been widely investigated in biomedical fields due to their similar physical
and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid …
and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid …
Unravelling cell migration: defining movement from the cell surface
F Merino-Casallo, MJ Gomez-Benito… - Cell adhesion & …, 2022 - Taylor & Francis
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …
The importance of 3D fibre architecture in cancer and implications for biomaterial model design
JC Ashworth, TR Cox - Nature Reviews Cancer, 2024 - nature.com
The need for improved prediction of clinical response is driving the development of cancer
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …
[HTML][HTML] 3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain
We describe a cellular contractile mechanism employed by fibroblasts and mesenchymal
cancer cells to migrate in 3D collagen gels. During 3D spreading, fibroblasts strongly deform …
cancer cells to migrate in 3D collagen gels. During 3D spreading, fibroblasts strongly deform …
Extracellular matrix mechanobiology in cancer cell migration
The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
chemically stimulating tumor cells, it also offers physical support that orchestrates the …
Collagen fibril orientation instructs fibroblast differentiation via cell contractility
Collagen alignment is one of the key microarchitectural signatures of many pathological
conditions, including scarring and fibrosis. Investigating how collagen alignment modulates …
conditions, including scarring and fibrosis. Investigating how collagen alignment modulates …
Passive stiffness of fibrotic skeletal muscle in mdx mice relates to collagen architecture
SE Brashear, RP Wohlgemuth… - The Journal of …, 2021 - Wiley Online Library
Key points The amount of fibrotic material in dystrophic mouse muscles relates to contractile
function, but not passive function. Collagen fibres in skeletal muscle are associated with …
function, but not passive function. Collagen fibres in skeletal muscle are associated with …
Matrix stiffness and architecture drive fibro-adipogenic progenitors' activation into myofibroblasts
Fibro-adipogenic progenitors (FAPs) are essential in supporting regeneration in skeletal
muscle, but in muscle pathologies FAPs the are main source of excess extracellular matrix …
muscle, but in muscle pathologies FAPs the are main source of excess extracellular matrix …
Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells
M Lopez-Cavestany, SB Hahn, JM Hope, NT Reckhorn… - iscience, 2023 - cell.com
Cells utilize calcium channels as one of the main signaling mechanisms to sense changes
in the extracellular space and convert these changes to intracellular signals. Calcium …
in the extracellular space and convert these changes to intracellular signals. Calcium …
Microengineering 3D Collagen Matrices with Tumor‐Mimetic Gradients in Fiber Alignment
Collagen fibers in the 3D tumor microenvironment (TME) exhibit complex alignment
landscapes that are critical in directing cell migration through a process called contact …
landscapes that are critical in directing cell migration through a process called contact …