Natural killer cells in cancer biology and therapy
SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
Natural killer cell homing and trafficking in tissues and tumors: from biology to application
GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …
against cancer. Although some evidence shows that NK cells can develop in secondary …
High-dimensional single-cell analysis of human natural killer cell heterogeneity
L Rebuffet, JE Melsen, B Escalière… - Nature …, 2024 - nature.com
Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to
microbes and tumors. Historically, their classification hinged on a limited array of surface …
microbes and tumors. Historically, their classification hinged on a limited array of surface …
A pan-cancer single-cell panorama of human natural killer cells
F Tang, J Li, L Qi, D Liu, Y Bo, S Qin, Y Miao, K Yu… - Cell, 2023 - cell.com
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor
progression. To depict their phenotypic and functional diversities in the tumor …
progression. To depict their phenotypic and functional diversities in the tumor …
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory
Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses
The treatment of low-risk primary prostate cancer entails active surveillance only, while high-
risk disease requires multimodal treatment including surgery, radiation therapy, and …
risk disease requires multimodal treatment including surgery, radiation therapy, and …
Natural killer cell immunotypes related to COVID-19 disease severity
Understanding innate immune responses in coronavirus disease 2019 (COVID-19) is
important to decipher mechanisms of host responses and interpret disease pathogenesis …
important to decipher mechanisms of host responses and interpret disease pathogenesis …
[HTML][HTML] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …
essential to understand the immunopathogenesis and clinical course of coronavirus disease …
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
S Notarbartolo, V Ranzani, A Bandera, P Gruarin… - Science …, 2021 - science.org
To understand how a protective immune response against SARS-CoV-2 develops over time,
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
Bone metastasis: mechanisms, therapies, and biomarkers
Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …